Predictive Biomarker Testing in Colorectal Cancer: KRAS and BRAF Mutation Frequency and Testing Algorithm in Developing Countries

Predictive biomarker testing is mandatory before initiating targeted therapy in metastatic colorectal cancer (mCRC). Mutation frequencies and their association with clinicopathological features vary widely across populations. In low socio-economic countries, appropriate selection of cases is important for biomarker testing....Continue reading →

Hematidrosis or Hematofolliculohidrosis: Report of the Second Case with Complete Histopathologic and Immunologic Studies and a Review of the Literature

Hematidrosis, or bloody sweat, is a rare phenomenon with enigmatic pathogenesis. We present our second case of hematidrosis in a 13-year-old Thai girl that had bloody sweat frequently observed on her back, hands, legs and feet. Skin biopsy revealed areas of hemorrhage in the panniculus and blood-filled spaces in the dermis....Continue reading →

Low-Grade Central Osteosarcoma of Ilium, A Case Report

Low-grade central osteosarcoma accounts for 1-2% of all osteosarcomas, and is usually found in long bones of extremities. To our best knowledge, low-grade central osteosarcoma of pelvic bone is unusually rare....Continue reading →

Thrombotic microangiopathy with Atypical Posterior Reversible Encephalopathy Syndrome (PRES) after kidney transplantation. A case report.

Neurological manifestation of thrombotic microangiopathy (TMA) after renal transplantation is rare and difficult to be distinguished from other conditions. A 51-year-old female with ESRD of unknown etiology received deceased donor kidney transplantation from a 57-year-old donor....Continue reading →

Gap Analysis Study before Implementation of Thailand’s National Guidelines for Point of Care Testing at Chiang Rai Province

The Bureau of Laboratory Quality Standards has published Thailand’s National Guidelines for Point-of-Care Testing (POCT) since August 2015. Still yet, the implementation of the guidelines is a great challenge....Continue reading →

Rate of Dyserythropoiesis-like Nuclear Changes in Erythroid Precursors in Bone Marrow

Dyserythropoiesis-like post-mortem changes in erythroid precursors at autopsy can look similar to certain kinds of pathologic processes. Objective: This study is to evaluate nuclear changes in erythroid precursors in marrow aspirate smears and histologic sections at different intervals...Continue reading →

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

The Akt/mTOR pathway is activated in many malignancies including oral squamous cell carcinoma (OSCC). Oral verrucous carcinoma (OVC) is a low grade variant of OSCC. However, the role of the Akt/mTOR pathway in OVC remains unknown. ...Continue reading →

...Continue reading →

Author : ,

Anaplastic lymphoma kinase (ALK) translocation in paediatric malignant peritoneal mesothelioma: a case report of novel ALK-related tumour spectrum

To report a case of paediatric malignant peritoneal mesothelioma (MPM) with evidence of anaplastic lymphoma kinase (ALK) translocation....Continue reading →

Endometriosis with gut obstruction: a case report of 38 years old woman with acute abdominal pain

A woman, age thirty-eight years old, came to the hospital with acute diarrhea and complained of having severe abdominal pain for two days. She had no underling disease and no history of alcohol or tobacco usage. She previously had surgery for a fracture of the right femur....Continue reading →

Author : Garan Phrommee , M.D. ,

Primary renal neuroendocrine tumor: A case report and literature review

Primary renal neuroendocrine tumor or primary renal carcinoid tumor is a very rare primary tumor of the kidney. This tumor appears to be associated with horseshoe kidney and the most common clinical features being abdominal pain or hematuria. Here, we report on the case of 63-yearold Thai female who presented...Continue reading →

Difficult case in the diagnosis of pineal tumor with ectomesenchymal differentiation: teratoma versus pineal anlage tumor.

Pineal region tumors are rare and heterogeneous including germ cell tumors, pineal parenchymal tumors and neuroepithelial tumors. Amongthe pineal region tumors, germ cell tumorssuch as germinoma and teratoma are the most common, followed by pineal parenchymal tumors. We have discusseda case of 20-year-old woman...Continue reading →

Astudy of prostatic cancer in radical prostatectomyspecimenand acorrelationwithpre-operativeserum PSA levelin Chiang Mai University Hospital

To assess arelationship between serum prostate specifi c antigen (PSA) levels and pathologic parameters in radical prostatectomy (RP) specimens for prostate cancer in Chiang Mai University Hospital, Chiang Mai, Thailand....Continue reading →

Placental villous hypermaturation in idiopathic spontaneous preterm births in Srinagarind Hospital

To determine the association between preterm births (PTBs) and placental villous hypermaturation (PVH), a pathological fi nding which suggests placental insuffi ciency....Continue reading →

Automated counting of Ki-67 labeling index compares with eyeballing estimation to predict behavior of pituitary adenoma.

Pituitary adenoma has been classified as benign according to slow-growing tumor. However, some atypical pituitary adenoma may have clinical aggressiveness such as parasellar invasion and high recurrence rate.Many studies have failed to demonstrate a correlation between Ki-67 labeling index and behavior of this tumor....Continue reading →

Specificity of cytologic features of metastatic lung adenocarcinoma in malignant pleural effusion

Metastatic lung adenocarcinoma is commonly presented with effusions. The cytologic examination of the fl uid is one of the fi rst diagnostic techniques attempted in these patients. Identifi cation of the cancer cells in pleural fl uid specimens, using minimal, less invasive and cost effective intervention is crucial especially...Continue reading →

Accuracy in distinguishing between primary adenocarcinoma of cervix and adenocarcinoma of endometrium from curettage specimen by immunohistochemistry

Endometrial and endocervical adenocarcinomas can seem histologically identical and it can be diffi cult to determine the primary site of origin based on morphology alone. As the distinction is signifi cant and cannot always be made on the basis of clinical fi ndings, various immunohistochemical panels have been proposed to aid in determining...Continue reading →

Prevalence of Microsatellite instability (MSI) determined by immunohistochemical staining of MSH6 and PMS2 in patients with colorectal adenocarcinoma

Microsatellite instability(MSI) is one of the genetic abnormalities that leads to colon cancer. The defect, known as mismatch repair genes(MMR) can be either sporadic or a germ line mutation. A immunohistochemical study is one of the methods to detect MMR defects. Lots of different treatment modalities and prognosis are needed to distinguish cancer...Continue reading →

Inflammatory bowel disease: Review of histologic features

Inflammatory bowel disease (IBD) is a chronic infl ammation of the digestive tract with ulcerative colitis (UC) and Crohn’s disease (CD) being among the two most common IBD conditions. To evaluate the effi cacy of diagnosis by histomorphology, the histologic features of ninety Thai patients with IBD were evaluated...Continue reading →

Impact of the 2011 IASLC/ATS/ERS International Multidisciplinary Classifi cation on small biopsies of primary lung cancer: experience in King Chulalongkorn Memorial Hospital from 2012-2014

The 2011 international association for the study of lung cancer/ American thoracic society/ European respiratory society (IASLC/ATS/ERS ) classifi cation changed the approach for defi nite histologic diagnosis of lung cancer. The objective of this article is to describe the impact of the 2011 IASLC/ATS/ERS classifi cation on small biopsy...Continue reading →

Pulmonary neuroendocrine hyperplasia in hemoglobin Bart-induced hydrops fetalis. A model for chronic intrauterine hypoxia

The pulmonary neuroendocrine system consists of pulmonary neuroendocrine cells (PNECs) and neuroendocrine bodies (NEBs) distributed throughout the respiratory epithelium which regulate lung growth and maturation in the antenatal period. Abnormalities in this system have been linked to many hypoxia-associated pediatric pulmonary disorders....Continue reading →

Comparison of embalming techniques between formaldehyde and salt solution in human liver and brain

Formaldehyde exposure is a risk factor for cancer in humans. Recent studies have revealed that salt solution can preserve human and animal tissues with a quality equal to formaldehyde. This study is the fi rst attempt to compare effectiveness between formaldehyde and salt solution preservation by quantitative measurement of tissue discoloration, ...Continue reading →

Agreement between Rapid On-site Evaluation and Final Cytologic Diagnosis of Salivary Gland Specimens

To evaluate diagnostic agreement and compare the performance (accuracy) between rapid onsite evaluation (ROSE) and the fi nal cytologic diagnosis of salivary gland specimens....Continue reading →

Discrepancies between clinical and autopsy diagnosis in traumatic death cases in Siriraj Hospital

Hospital autopsy has been questioned regarding its utility, effectiveness, and validity. However, some discrepancies between clinical and autopsy diagnosis has been shown in previous study.While forensic autopsy, which is mostly done in traumatic death, has not been evaluated for its usefulness, the authors would like to determine...Continue reading →

P-cadherin and CD10 expression to distinguish between ductal carcinoma in situ and invasive ductal carcinoma of the breast

To utilize immunohistochemistry techniques using P-cadherin and CD10 antibodies for evaluating the expression in DCIS and IDC for distinguishing between these entities...Continue reading →

Evaluation of Adequacy and Diagnostic Histopathology Results of Endometrial Specimens Obtained by Endometrial Aspiration Procedure in Srinagarind Hospital, Khon Kaen University.

The purpose of this investigation is to evaluate the adequacy of endometrial specimens obtained by endometrial aspiration procedures using Pipelle® Endometrial Suction Currette, to determine the minimum microscopic area of endometrial fragments adequate for diagnosis, and to make a correlation between the initial diagnoses of the...Continue reading →

Molecular diagnosis of synovial sarcoma: A comparative study with histologic correlation in Ramathibodi Hospital

Synovial sarcoma (SS) is a relatively common sarcoma of soft tissue arising on extremities of young adult, which is often diagnosed by histology and immunohistochemistry. Synovial sarcoma can have various locations and may cause diagnostic dilemma in tumors arising on unusual locations. In this study, we evaluate the application of molecular test...Continue reading →

Clinicopathological Correlation of Glomerular Mesangial C4d Staining and renal outcome in IgA Nephropathy: A retrospective Cohort Study in Ramathibodi Hospital

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, particularly in Asia. Clinical manifestations vary from asymptomatic to end stage renal disease (ESRD). Currently, several studies have introduced new markers to predict prognosis including C4d which is correlated with poor clinical course....Continue reading →

Evaluation of thyroid fine needle aspiration cytology by the Bethesda reporting system: a retrospective analysis of rates and outcomes from the King Chulalongkorn Memorial Hospital

Fine-needle aspiration (FNA) cytology is a gold standard for preoperative evaluation of thyroid nodules. Recently introduced, the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has attempted to standardize reporting and cytological criteria in aspiration smears. This reporting format suggested six diagnostic categories, briefl y defi ned as follows...Continue reading →

Clinicopathological Features of Primary Thyroid Lymphomas in Thailand

Primary non-Hodgkin lymphoma (NHL) of the thyroid is a rare tumor. Some studies show association between thyroid lymphomas and concomitant thyroid diseases, mainly lymphocytic thyroiditis. However, this tumor has not been studied in Thailand. .Therefore, herein, we reviewed clinicopathological features of primary thyroid lymphoma including associated thyroid lesions....Continue reading →

Fine Needle Aspiration and Core Needle Biopsy for Diagnosis of Mediastinal Mass in Thailand

To evaluate diagnostic accuracy of fi ne needle aspiration (FNA) and core needle biopsy (CNB) in mediastinal lesions. Material and Methods: From October 2006 to September 2015, there were 45 cases of FNA and 87 cases of CNB included in this retrospective study. Results of FNA and CNB were compared with subsequent resection specimen...Continue reading →

Hepatic injury in patients with colorectal liver metastasis in Thailand

The treatment of colorectal liver metastasis is surgical resection. The chemotherapy can convert unresectable lesions to resectable lesions. However chemotherapy also causes liver injuries in remaining liver parenchyma, such as steatosis, steatohepatitis and sinusoidal dilation. These lesions cannot be distinguished from other causes,...Continue reading →

Rate of Dyserythropoiesis-like Nuclear Changes in Erythroid Precursors in Bone Marrow

Dyserythropoiesis-like post-mortem changes in erythroid precursors at autopsy can look similar to certain kinds of primary marrow diseases. This study is designed to evaluate nuclear changes in erythroid precursors in marrow aspirate smears and histologic sections at different intervals after taken out from the body (delayed fi xation) simulating post-mortem changes....Continue reading →

Update in Thymoma for Surgical Pathologists

Thymoma is the most common mediastinal tumor in adulthood. By definition, it is a thymic epithelial neoplasm that displays at least some characteristics of normal thymus. Microscopically it comprises an admixture of thymic epithelial cells and immature T lymphocytes in various proportions and demonstrates marked intratumoral heterogeneity...Continue reading →

Acute and subchronic oral toxicity of xanthones extracted from the pericarp of Garcinia mangostana Linn.in rat

The purpose of this research was to study the acute and subchronic toxicity of crude mangosteen pericarp hydro extract, and determine the appropriate and safe amount of extract that may be consumed, through testing with Sprague Dawley rats of both sexes. The soft layer of the inner pericarp mangosteen fruits was immersed in water and boiled at 70 OC, and...Continue reading →

Contribution of MYC FISH in Pathological Diagnosis of Burkitt Lymphoma

Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma typically with MYC rearrangement. Distinction between BL and diffuse large B cell lymphoma (DLBCL) is not infrequently encountered in routine practice. In this communication, we report our experience with the MYC break-apart probe FISH in the diagnosis of BL in 19 cases of...Continue reading →

Myocardial infarction without coronary artery atherosclerosis: pathological aspect

Myocardial infarction (MI) is a clinico-pathological condition resulted from an irreversible ischemic injury to cardiac myocytes. Myocardial infarction with normal coronary artery on angiogram (MINCA) is a widelyaccepted clinical term used to describe a group of patients presenting with the MI symptoms and signs but having a normal angiogram....Continue reading →

Comparison of α-smooth muscle actin expression between squamous cell carcinoma and pseudoepitheliomatous hyperplasia

To evaluate the usefulness of α-smooth muscle actin (α-SMA) expression of reactive myofibroblastic cells within desmoplastic reaction tissue for distinction between invasive squamous cell carcinoma (SCC) and pseudoepitheliomatous hyperplasia (PEH)....Continue reading →

Standardization of the Colorectal Carcinoma Surgical Pathology Report

In 2010 Department of Pathology Siriraj Hospital had introduced a standardization program for reporting colorectal carcinoma. Then the completeness and accuracy of pathology reports were assessed. Slides were reviewed for accuracy of pT stage and rectal circumferential margin status. After standardization program the percentage of pT4 lesion...Continue reading →

Axillary lymph node ratio is an independent prognostic factor in Thai breast cancer patients

The number of metastatic lymph nodes to the total number of dissected axillary lymph nodes (lymph node ratio: LNR) is described as an independent prognostic factor in breast cancer patients, beside the traditional account of the number of axillary lymph node metastasis (pN stage). We investigated the correlation between LNR and prognosis among Thai...Continue reading →

Predictive Relevance of Tumor-infiltrating Lymphocytes in Breast Cancer

To determine the prognostic significance of the immunophenotype, density and distribution of tumor-infiltrating lymphocytes (TILs) in breast cancer samples....Continue reading →

Determination of Asbestos Bodies in Autopsy Lung Fluid

The finding of asbestos bodies in lung fluid aspirates represents definite evidence of having prior exposure to asbestos, and having asbestos fibers entering the bronchial tree. After entering the lung, fibers undergo a coating process with ferritin protein to form asbestos bodies. The present study was carried out with the aim of determining...Continue reading →

Angioimmunoblastic T-Cell Lymphoma: an Epstein-Barr Virus-Associated, Bilineage Lymphoid Neoplasm

In this study, 50 cases of angioimmunoblastic T-cell lymphoma (AITL) were investigated for histological patterns, their association with Epstein-Barr virus (EBV) infection, B cell and T cell clonalities, and the clini- cal outcomes. Three histological patterns were identified: the classical pattern (34 cases), large-cell rich pat- tern (14 cases)...Continue reading →

Increases of pro-inflammatory cytokine expression in hippocampus following chronic paracetamol treatment in rats

Paracetamol is one of the most popular drugs used for treatment of pain and headaches. Recent evidences have indicated that long term treatment with this drug can induce the neurotoxic effect in the brain including in the hippocampal neurons, however the mechanism underlying its neurotoxic effect is still unclear. The present study aimed...Continue reading →

Comparison of Histopathology and Mammography for breast lesions. Retrospective study of 250 cases in Srinagarind Hospital, Khon Kaen, Thailand.

To assess the pathologic outcome of BI-RADS mammographic classification and the success of stereotactic biopsy for such lesions. Materials and...Continue reading →

Chondrosarcoma of distal phalanx with imaging study; a report of rare case with review of the literature

Chondrosarcoma of distal phalanx is extremely rare and to our best knowledge there was only one case having magnetic resonance ( MR ) imaging study. We report a case of 56-year-old woman developing chondrosarcoma of distal phalanx of the left ring finger. The radiographic and imaging studies highly suggested chondrosarcoma and amputation of distal...Continue reading →

Impact of CpG site specific methylation on silencing protein expression of GSTP1 in breast cancer

From previous study with Methylation specific polymerase chain reaction (MSP), there were cases of DNA methylation showing positive protein expression. Some CpG sites of the primer were speculated to have no effect on protein expression....Continue reading →

A case of intestinal perforation due to age-related EBV-associated B-cell lymphoproliferative disorder

Age-related Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD) is a recently novel EBV-positive clonal B-cell proliferation, occurring in patients >50 years old without any known immunodeficiency or prior lymphoma. The disease is believed to be related to immunological deterioration derived from the aging process and has aggressive...Continue reading →

Is immunohistochemistry mandatory in staging bone marrow trephine biopsy of patients with diffuse large B-cell lymphoma (DLBCL)

...Continue reading →

Primary sinonasal mucosal melanoma with CD138 expressed plasmacytoid cells: a case report and review of literature

Primary sinonasal mucosal melanoma is a rare neoplasm. Like in other sites of malignant melanoma, the histopathology is variable and when lacking of melanin pigment, particularly in small biopsy specimen mimicks many neoplasms. Immunohistochemical staining plays an important role. Many immunomarkers, including S-100, HMB-45 and Melan-A should be...Continue reading →

Increased eosinophil levels in HIV-infected patients with high CD4/CD8 ratio Study from 564 patients in Ramathibodi Hospital.

Blood from 564 patients infected with human immunodeficiency virus (HIV) were studied for laboratory analysis. The hematological changes including white blood cell count (WBC), percentage and absolute number of lymphocyte and eosinophil were determined by using the Technicon H*3 RTX hematological analyzer. Analysis of blood cell parameters...Continue reading →

Advantage of frozen section in management of thyroid nodule with preoperative fine needle aspiration in Siriraj Hospital, Bangkok, Thailand

We aimed to evaluate the role of frozen section (FS) and preoperative fine-needle aspiration cytology (FNA) in thyroid nodular lesions. ...Continue reading →

Sclerosing Polycystic Adenosis of the Parotid Gland: Report of A Case with Multifocality

Sclerosing polycystic adenosis (SPA) is a rare tumor-like lesion of the salivary gland that bears a histomorphological resemblance to fibrocystic disease and sclerosing adenosis of the breast. The lesion is widely considered to be a pseudoneoplastic inflammatory process. However, foci of epithelial dysplasia and carcinoma in situ can occur in the...Continue reading →

Primary Testicular NK/T-cell Lymphoma presented as testicular abscess: A Case Report and Literature Review of 33 cases

Primary testicular NK/T-cell lymphoma is rare. We report a 61-year-old Thai man who presented with right testicular abscess clinically but tissue obtained from incision and drainage was proven to be NK/T-cell lymphoma. The lymphoma cells were small to medium in size and showed angiocentricity with associated necrosis. The lymphoma cells were CD3+...Continue reading →

Diagnostic accuracy of fine needle aspiration cytology of salivary glands

Fine needle aspiration (FNA) cytology of suspected salivary gland lesions has an established role in preoperative diagnosis and management of patients. However diverse morphological patterns and overlapping features make it a challenging job, to give a precise diagnosis, at times. The aim of the present study is to investigate the accuracy...Continue reading →

The role of Immunohistochemistry in diagnosis of renal cell carcinoma subtypes.

To determine the validity of immunohistochemistry in classifying Renal cell carcinoma (RCC) subtypes. Methods: Eighty-three cases of RCC were retrieved. Immunohistochemical staining of Vimentin, CD10, CK7, P504s, Parvalbumin, TFE3, and CD117 were done by using tissue microarray blocks. RCC subtypes were placed and compared with the previous diagnosis....Continue reading →

Loop-mediated isothermal amplification for detection of Mycobacterium tuberculosis and evaluation in paraffin-embedded lymph nodes

Tuberculosis is a treatable disease, but remains a major cause of mortality. Culture for Mycobacterium is needed to make a definitive diagnosis; thus, loop-mediated isothermal amplification (LAMP) was attempted for its detection in formalin-fixed, paraffin-embedded (FFPE) samples. Materials and method: Archival FFPE blocks were used from 64 patients...Continue reading →

Sperm Extraction from Absorbed Filter Paper by Shaking Method

This study would like to to show an easy and effective way (method) for sperm extraction. The method could be used as basic extraction of sperm from absorbed material; such as swab, cotton or fi lter paper. Materials and...Continue reading →

Molecular diagnosis of synovial sarcoma: A comparative study with histologic correlation in Ramathibodi Hospital

Synovial sarcoma (SS) is a relatively common sarcoma of soft tissue arising in extremities of young adult, which is often diagnosed by histology and immunohistochemistry (IHC). Synovial sarcoma can be found in various locations and may cause diagnostic dilemma in tumors arising in unusual locations. In this study, we evaluated the application of...Continue reading →

Comparison of triple-dose single-donor platelet collection by the AmicusTM and the Trima Accel® blood-cell separators

The purpose of this study was to compare triple-dose single-donor platelet collection using Amicus™ and Trima Accel® blood-cell separators....Continue reading →

The Use of Pilocarpine Eye Drop for Estimation of Time Since Death

To study of estimation of time since death by Pilocarpine eye dropping....Continue reading →

The accuracy of MUC5AC, CEA and vimentin expressions in the differentiation of endocervical and endometrial adenocarcinoma

Endocervical adenocarcinoma (ECA) and endometrial adenocarcinoma (EMA) have differences in etiologies, behavior and treatments. It needs to preoperative distinguish between these two tumors because of the overlapping morphological features....Continue reading →

Soft tissue vascular malformations differentiating flow types by MR imaging and comparison with histopathology

To evaluate the MR imaging features of pathologically diagnosed high and low flow vascular malformations....Continue reading →

Similar expression of cytokeratin (CK7+/CK20+), Her-2, P53 and CA 125 in intrahepatic and extrahepatic cholangiocarcinoma: an immunohistochemical study

To evaluate cytokeratin CK7+/CK20+ and common oncogene, tumor suppressor gene and tumor marker in intrahepatic and extrahepatic cholangiocarcinoma. In 2009, the American Joint Committee on Cancer regrouped extrahepatic cholangiocarcinoma (EH-CCA) by placing hilar...Continue reading →

Impact of Quality and Quantity of DNA samples on KRAS Mutation Analysis

Many techniques based on polymerase chain reaction (PCR) have been utilized to detect KRAS mutation, a negative predictor of anti-EGFR treatment efficacy. Inaccurate mutation test can result from inefficient PCR amplification in poor quality DNA due to formalin-induced DNA degradation or the presence of PCR inhibitors....Continue reading →

Hepatitis B Virus infection is not a risk factor in liver fluke-associated cholangiocarcinoma – a comparative study of P53 mutation between groups with Opisthorchis viverrini and HBV infection

To investigation the role of HBV infection as a risk factor in liver fluke-associated cholangiocar-cinoma In Northeast (NE) Thailand, people are exposed to numerous risk factors for cholangiocarcinoma, such as: infestation with the liver fluke, Opisthorchis vivenini, hepatitis B virus (HBV) and hepatitis c virus (HCV) infection, and nitrosamine...Continue reading →

GLUT1 expression in non-Hodgkin lymphoma diffuse large B-cell lymphoma clinical and International Prognostic Index analysis

High levels of glucose transporter 1 (GLUT1) expression are correlated with aggressiveness and poor outcomes in many malignancies. There were few studies of this correlation in non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and have heterogeneity in clinical outcomes....Continue reading →

Comparison of α-SMA expression between squamous cell carcinoma and pseudoepitheliomatous hyperplasia

The differentiation between invasive squamous cell carcinoma and reactive benign squamous proliferation has caused difficulties in general routine practice of pathology. Among several pathologic changes, desmoplastic reaction which represents myofibroblastic cell proliferation is one indicator for invasiveness of the cancer cells....Continue reading →

Comparison between visual assessment and image analysis in evaluating renal interstitial fibrosis and predicting renal outcomes in lupus nephritis

ment and image analysis methods in lupus nephritis patients....Continue reading →

The accuracy of MUC5AC, CEA and vimentin expressions in the differentiation of endocervical and endometrial adenocarcinoma

Endocervical adenocarcinoma (ECA) and endometrial adenocarcinoma (EMA) have differences in etiologies, behavior and treatments. It needs to preoperative distinguish between these two tumors because of the overlapping morphological features....Continue reading →

A comparison of HLA-B*15:02 screening tests before prescribing carbamazepine

HLA-B*15:02 is the most significant biomarker associated with carbamazepine-induced severe cutaneous drug reaction in Asians. A number of HLA-B*15:02 screening tests have been developed to prevent the drug reaction in clinical practice. However, no comparison of these methods has to date been reported....Continue reading →

Traumatic asphyxial death from two-wheel ‘walking behind’ tractor

A 41-year-old man was found suspended 15 cm above the floor, hanging from the long handle-bars of a twowheel ‘walking behind’ tractor. The floor was downward sloping and muddy, which caused the tractor to dig into the floor, raising the long handle bars under the arms of the victim, and pushing him against a pillar....Continue reading →

Non-functioning adrenal cortical adenoma arising in adrenohepatic fusion, mimicking hepatocellular carcinoma – a case report

Adrenal cortical adenoma arising in adrenohepatic fusion is an exceedingly rare occurrence. It can potentially be misinterpreted as hepatocellular carcinoma as they share radiologic and histologic similarities. We report an incidental subcapsular adrenal cortical adenoma arising in adrenohepatic fusion tissue in segment 7 of the liver...Continue reading →

Mantle cell lymphoma presenting as multiple lymphomatous polyposis of colon: A case report.

Mantle cell lymphoma is a clinically aggressive lymphoma with a poor prognosis. Secondary involvement of gastrointestinal tract by this neoplasm is not uncommon but the primary involvement with distinguished multiple lymphomatous polyposis is unusual. We report a case of mantle cell lymphoma presenting as multiple lymphomatous...Continue reading →

Sudden Death from Retroperitoneal Hemorrhage Due to Necrotizing Pancreatitis

We report a case of sudden death from retroperitoneal hemorrhage in 73-year-old male due to rupture of peri-pancreatic artery in acute necrotizing pancreatitis. This appears to be the first case report of sudden death from retroperitoneal hemorrhage due to pancreatitis. The rupture site was not identifiable by gross-exami- nation but it was confirmed...Continue reading →

Neuroendocrine Tumor of the Gallbladder with Hepatic Metastases: A Case Report

A 68-year-old woman presented with hepatic metastasis. She had been performed cholecystectomy at a provincial hospital for symptomatic gallstones and was diagnosed as poorly differentiated adenocarcinoma of the gallbladder. The follow-up hepatic segmentectomy revealed a malignant small round tumor composed of nests of cells containing small nuclei...Continue reading →

CD43 Expression in Malignant Melanoma: A Diagnostic Pitfall

CD43 is commonly concerned as a marker for hematopoietic cells and, at times, a preferential T-cell marker. However, a number of non-hematologic cancers, mostly carcinoma, can express CD43. Recently, a case of malignant melanoma mimicking malignant lymphoma by cytomorphology was reported to express CD43 as well as melanoma markers but the other hematologic...Continue reading →

Bursitis with pseudosarcomatous fibroblastic proliferation; a case report

Pseudosarcomatous fibroblastic proliferation (PSFP) is a quite common lesion found in various locations in- cluding soft tissue, bone and other organs and often raises a difficult differential diagnosis with malignancy. However, PSFP has not been described in tissue related to bursitis. We report a case of 31-year-old male who developed a cystic...Continue reading →

Incomplete pentalogy of Cantrell: a case report

Pentalogy of Cantrell is a rare congenital syndrome characterized by defects involving the supra-umbilical abdominal wall, lower sternum, anterior diaphragm, pericardium, and the intra-cardiac anomalies. The ensuing congenital heart disease is a source of major morbidity. The full spectrum of the syndrome is rare while incomplete expression of the...Continue reading →

Primary central nervous system lymphoma presenting with panhypopituitarism and diabetes insipidus

Lymphoma involving the hypothalamus is very rare. We present a case of a 48-year-old man with primary central nervous system lymphoma (PCNSL) presenting with hypothalamic and pituitary stalk lesions with frontal masses, causing diabetes insipidus and panhypopituitarism. Brain MRI with gadolinium enhancement demonstrated vivid enhancing hypothalamic and...Continue reading →

Disseminated Tuberculosis in a Mother with Diffuse Large B-cell Lymphoma resulting in Placental and Inferred Congenital Tuberculosis: An Autopsy Case Report

Tuberculosis of the placenta is a rare condition which mainly occurs in the immunosuppressed individuals especially in acquired immune deficiency syndrome (AIDS) and hematologic malignancy9. Tuberculosis can spread to the fetus via hematogenous or cervicovaginal route and result in congenital tuberculosis....Continue reading →

Update in Thymoma for Surgical Pathologists

Thymoma is the most common mediastinal tumor in adulthood. By defi nition, it is a thymic epithelial neoplasm that displays at least some characteristics of normal thymus. Microscopically it comprises an admixture of thymic epithelial cells and immature T lymphocytes in various proportions and demonstrates marked intratumoral...Continue reading →

Transformation in Malignant Lymphoma: Morphologic Approach

Morphologic approach is still very crucial to detect transformation in malignant lymphoma. With the knowledge of each malignant lymphoma type, especially the clinical course, a number of lymphoma can have histologic progression as evidence of transformation as follow: large cell transformation, blastic transformation, and histiocytic...Continue reading →

The Many Faces (and Origins) of Adenocarcinoma in the Liver: Pattern Approach to Diagnosis on Small Tissue Samples

Focal liver lesions can be solitary or multiple, solid or cystic, congenital or acquired, and range from cysts, hamartomas, hyperplastic nodules and inflammatory entities to tumors and tumor-like lesions. The background liver may be normal or diseased. An algorithmic approach based on pattern recognition and cell profiling is outlined for the ...Continue reading →

Author : Aileen Wee , MB , BS , FRCPath , FRCPA* ,

Developing Pathology Services in Resource Poor Settings An Invitation to the International Academy of Pathology Meeting Bangkok 2014

The delivery of high quality laboratory medicine services in developing countries of low economic resources poses particular problems. International efforts to help develop pathology take many forms and include educa- tional and training initiatives by a number of organisations, although these are often disparate. In this article we will...Continue reading →

A practical approach to undifferentiated tumors: A review on helpful markers and common pitfalls

The term “undifferentiated” tumor is commonly used by pathologists when a tumor lacking evidence of lineage differentiation on the basis of routine light microscopic morphology is encountered. Immunohisto- chemistry plays an important role in elucidating the true nature of the undifferentiated tumor that is crucial for clinical management....Continue reading →

Diagnostic Pitfalls of Prostatic Adenocarcinoma in Biopsy Specimens

Prostatic adenocarcioma is a very common male cancer worldwide. Biopsy remains the most reliable means in making definite diagnosis. In the prostate-specific antigen (PSA) screening era, the rate of prostate biopsies rapidly increases, resulting in early detection of very small tumors. In the same time, general pathologists are forced to face...Continue reading →

Frontoethmoidal encephalomeningocele histopathology and proposed mechanism of developing lesion

The purpose of this study is to describe histopathological fi ndings of frontoethmoidal meningoencephalocele (FEEM), and to correlate with the embryogenesis. The study materials were gathered from 86 cases of FEEM, during 1995-2005. The histopathology was observed in terms of the pattern of the lesion, the relation to the skin and surrounding soft tissue,...Continue reading →

Pulmonary alveolar proteinosis coexisting with homozygous hemoglobin E

Pulmonary alveolar proteinosis (PAP) is an uncommon lung disorder of obscure and possibly diverse causes characterized by abnormal accumulation of lipoproteinaceous surfactant material in alveoli. The prevalence of acquired PAP has been estimated to be 0.37 per 100,000 populations. We present a case of PAP coexisting in homozygous hemoglobin (Hb) E....Continue reading →

Relationship between promoter methylation and protein expression of glutathione S-transferase gene class P1 in breast cancer

Glutathione S-transferase gene class P1 (GSTP1) encodes glutathione S-transferase P1 (GSTP1) that catalyses detoxifying metabolism of glutathione. The lack of GSTP1 expression is linked to carcinogen-esis and is related to promoter methylation. The previous studies of GSTP1 hypermethylation in breast cancer reveal diverse results and suspicious...Continue reading →

The effect of calcitonin upon the proliferation of giant cell tumor ; Preliminary of 9 cases

Giant cell tumor is one of the most common primary bone tumors in adult. Current therapy is still curettage and bone graft packing with adjuvant chemical and thermal cautery. However, the rate of recurrence is rather high ranging from 20 to 85 % and many attempts have been made to decrease this rate. Some inves- tigators showed that the cells of...Continue reading →

Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com