Category Archives: Original articles

Predictive Biomarker Testing in Colorectal Cancer: KRAS and BRAF Mutation Frequency and Testing Algorithm in Developing Countries

Predictive biomarker testing is mandatory before initiating targeted therapy in metastatic colorectal cancer (mCRC). Mutation frequencies and their association with clinicopathological features vary widely across populations. In low socio-economic countries, appropriate selection of cases is important for biomarker testing....Continue reading →

Acute and subchronic oral toxicity of xanthones extracted from the pericarp of Garcinia mangostana Linn.in rat

The purpose of this research was to study the acute and subchronic toxicity of crude mangosteen pericarp hydro extract, and determine the appropriate and safe amount of extract that may be consumed, through testing with Sprague Dawley rats of both sexes. The soft layer of the inner pericarp mangosteen fruits was immersed in water and boiled at 70 OC, and...Continue reading →

Contribution of MYC FISH in Pathological Diagnosis of Burkitt Lymphoma

Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma typically with MYC rearrangement. Distinction between BL and diffuse large B cell lymphoma (DLBCL) is not infrequently encountered in routine practice. In this communication, we report our experience with the MYC break-apart probe FISH in the diagnosis of BL in 19 cases of...Continue reading →

Myocardial infarction without coronary artery atherosclerosis: pathological aspect

Myocardial infarction (MI) is a clinico-pathological condition resulted from an irreversible ischemic injury to cardiac myocytes. Myocardial infarction with normal coronary artery on angiogram (MINCA) is a widelyaccepted clinical term used to describe a group of patients presenting with the MI symptoms and signs but having a normal angiogram....Continue reading →

Comparison of α-smooth muscle actin expression between squamous cell carcinoma and pseudoepitheliomatous hyperplasia

To evaluate the usefulness of α-smooth muscle actin (α-SMA) expression of reactive myofibroblastic cells within desmoplastic reaction tissue for distinction between invasive squamous cell carcinoma (SCC) and pseudoepitheliomatous hyperplasia (PEH)....Continue reading →

Standardization of the Colorectal Carcinoma Surgical Pathology Report

In 2010 Department of Pathology Siriraj Hospital had introduced a standardization program for reporting colorectal carcinoma. Then the completeness and accuracy of pathology reports were assessed. Slides were reviewed for accuracy of pT stage and rectal circumferential margin status. After standardization program the percentage of pT4 lesion...Continue reading →

Axillary lymph node ratio is an independent prognostic factor in Thai breast cancer patients

The number of metastatic lymph nodes to the total number of dissected axillary lymph nodes (lymph node ratio: LNR) is described as an independent prognostic factor in breast cancer patients, beside the traditional account of the number of axillary lymph node metastasis (pN stage). We investigated the correlation between LNR and prognosis among Thai...Continue reading →

Predictive Relevance of Tumor-infiltrating Lymphocytes in Breast Cancer

To determine the prognostic significance of the immunophenotype, density and distribution of tumor-infiltrating lymphocytes (TILs) in breast cancer samples....Continue reading →

Determination of Asbestos Bodies in Autopsy Lung Fluid

The finding of asbestos bodies in lung fluid aspirates represents definite evidence of having prior exposure to asbestos, and having asbestos fibers entering the bronchial tree. After entering the lung, fibers undergo a coating process with ferritin protein to form asbestos bodies. The present study was carried out with the aim of determining...Continue reading →

Angioimmunoblastic T-Cell Lymphoma: an Epstein-Barr Virus-Associated, Bilineage Lymphoid Neoplasm

In this study, 50 cases of angioimmunoblastic T-cell lymphoma (AITL) were investigated for histological patterns, their association with Epstein-Barr virus (EBV) infection, B cell and T cell clonalities, and the clini- cal outcomes. Three histological patterns were identified: the classical pattern (34 cases), large-cell rich pat- tern (14 cases)...Continue reading →

Increases of pro-inflammatory cytokine expression in hippocampus following chronic paracetamol treatment in rats

Paracetamol is one of the most popular drugs used for treatment of pain and headaches. Recent evidences have indicated that long term treatment with this drug can induce the neurotoxic effect in the brain including in the hippocampal neurons, however the mechanism underlying its neurotoxic effect is still unclear. The present study aimed...Continue reading →

Comparison of Histopathology and Mammography for breast lesions. Retrospective study of 250 cases in Srinagarind Hospital, Khon Kaen, Thailand.

To assess the pathologic outcome of BI-RADS mammographic classification and the success of stereotactic biopsy for such lesions. Materials and...Continue reading →

Impact of CpG site specific methylation on silencing protein expression of GSTP1 in breast cancer

From previous study with Methylation specific polymerase chain reaction (MSP), there were cases of DNA methylation showing positive protein expression. Some CpG sites of the primer were speculated to have no effect on protein expression....Continue reading →

Increased eosinophil levels in HIV-infected patients with high CD4/CD8 ratio Study from 564 patients in Ramathibodi Hospital.

Blood from 564 patients infected with human immunodeficiency virus (HIV) were studied for laboratory analysis. The hematological changes including white blood cell count (WBC), percentage and absolute number of lymphocyte and eosinophil were determined by using the Technicon H*3 RTX hematological analyzer. Analysis of blood cell parameters...Continue reading →

Advantage of frozen section in management of thyroid nodule with preoperative fine needle aspiration in Siriraj Hospital, Bangkok, Thailand

We aimed to evaluate the role of frozen section (FS) and preoperative fine-needle aspiration cytology (FNA) in thyroid nodular lesions. ...Continue reading →

Diagnostic accuracy of fine needle aspiration cytology of salivary glands

Fine needle aspiration (FNA) cytology of suspected salivary gland lesions has an established role in preoperative diagnosis and management of patients. However diverse morphological patterns and overlapping features make it a challenging job, to give a precise diagnosis, at times. The aim of the present study is to investigate the accuracy...Continue reading →

The role of Immunohistochemistry in diagnosis of renal cell carcinoma subtypes.

To determine the validity of immunohistochemistry in classifying Renal cell carcinoma (RCC) subtypes. Methods: Eighty-three cases of RCC were retrieved. Immunohistochemical staining of Vimentin, CD10, CK7, P504s, Parvalbumin, TFE3, and CD117 were done by using tissue microarray blocks. RCC subtypes were placed and compared with the previous diagnosis....Continue reading →

Loop-mediated isothermal amplification for detection of Mycobacterium tuberculosis and evaluation in paraffin-embedded lymph nodes

Tuberculosis is a treatable disease, but remains a major cause of mortality. Culture for Mycobacterium is needed to make a definitive diagnosis; thus, loop-mediated isothermal amplification (LAMP) was attempted for its detection in formalin-fixed, paraffin-embedded (FFPE) samples. Materials and method: Archival FFPE blocks were used from 64 patients...Continue reading →

Sperm Extraction from Absorbed Filter Paper by Shaking Method

This study would like to to show an easy and effective way (method) for sperm extraction. The method could be used as basic extraction of sperm from absorbed material; such as swab, cotton or fi lter paper. Materials and...Continue reading →

Molecular diagnosis of synovial sarcoma: A comparative study with histologic correlation in Ramathibodi Hospital

Synovial sarcoma (SS) is a relatively common sarcoma of soft tissue arising in extremities of young adult, which is often diagnosed by histology and immunohistochemistry (IHC). Synovial sarcoma can be found in various locations and may cause diagnostic dilemma in tumors arising in unusual locations. In this study, we evaluated the application of...Continue reading →

Comparison of triple-dose single-donor platelet collection by the AmicusTM and the Trima Accel® blood-cell separators

The purpose of this study was to compare triple-dose single-donor platelet collection using Amicus™ and Trima Accel® blood-cell separators....Continue reading →

Frontoethmoidal encephalomeningocele histopathology and proposed mechanism of developing lesion

The purpose of this study is to describe histopathological fi ndings of frontoethmoidal meningoencephalocele (FEEM), and to correlate with the embryogenesis. The study materials were gathered from 86 cases of FEEM, during 1995-2005. The histopathology was observed in terms of the pattern of the lesion, the relation to the skin and surrounding soft tissue,...Continue reading →

Relationship between promoter methylation and protein expression of glutathione S-transferase gene class P1 in breast cancer

Glutathione S-transferase gene class P1 (GSTP1) encodes glutathione S-transferase P1 (GSTP1) that catalyses detoxifying metabolism of glutathione. The lack of GSTP1 expression is linked to carcinogen-esis and is related to promoter methylation. The previous studies of GSTP1 hypermethylation in breast cancer reveal diverse results and suspicious...Continue reading →

The effect of calcitonin upon the proliferation of giant cell tumor ; Preliminary of 9 cases

Giant cell tumor is one of the most common primary bone tumors in adult. Current therapy is still curettage and bone graft packing with adjuvant chemical and thermal cautery. However, the rate of recurrence is rather high ranging from 20 to 85 % and many attempts have been made to decrease this rate. Some inves- tigators showed that the cells of...Continue reading →

Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com