Neuroendocrine Tumor of the Gallbladder with Hepatic Metastases: A Case Report

Publish : December 15, 2014
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Komson Wannasai1, Witanee Na Chiang Mai2, Sunhawit Junrungsee3, Sarawut Kongkarnka1, Nirush Lertprasertsuke
1Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
2Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
3Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Received : 15 September 2014 ; Accepted : 25 October 2014


Case presentation: A 68-year-old woman presented with hepatic metastasis. She had been performed cholecystectomy at a provincial hospital for symptomatic gallstones and was diagnosed as poorly differentiated adenocarcinoma of the gallbladder. The follow-up hepatic segmentectomy revealed a malignant small round tumor composed of nests of cells containing small nuclei with fine granular chromatin and inconspicuous nucleoli. The tumor cells were immunoreactive for chromogranin A. Metastatic small cell carcinoma was diagnosed. The gallbladder lesion was reviewed and the diagnosis was revised to neuroendocrine carcinoma (NEC), small cell type. Conclusion: Neuroendocrine tumors/NEC of the gallbladder are uncommon and clinically and surgically indistinguishable from carcinoma of the gallbladder. Patients usually present with the common gallbladder symptomatology. This tumor has a bad prognosis and it is essential that the correct diagnosis be made on radiographic and histopathological grounds with immunohistochemical confirmation.


Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
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