The effect of calcitonin upon the proliferation of giant cell tumor ; Preliminary of 9 cases

Publish : December 15, 2012
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Visit Rangsinaporn, M.D.* Thanya Subhadrabandhu, M.D.** Patarawan Woratanarat, M.D.** Vorachai Sirikulchayanonta, M.D.***

* Department of Orthopaedics, Faculty of Madicine, Srinakarinwirot University, Thailand 

**Department of Orthopaedics, Faculty of Madicine, Ramathibodi Hospital, Mahidol University, Thailand

***Department of Pathology, Faculty of Madicine, Ramathibodi Hospital, Mahidol University, Thailand




Giant cell tumor is one of the most common primary bone tumors in adult. Current therapy is still curettage and bone graft packing with adjuvant chemical and thermal cautery. However, the rate of recurrence is rather high ranging from 20 to 85 % and many attempts have been made to decrease this rate. Some inves- tigators showed that the cells of giant cell tumor share similarity to osteoclasts in terms of phenotypic expres- sions and calcitonin receptor. In addition, calcitonin was reported to cause regression and degeneration of this tumor. Our study is aimed to evaluate the effect of calcitonin upon this tumor by comparing the number of positive cells in PCNA staining between pre and post calcitonin administrations. The result revealed significant decrease in number of positive cells after calcitonin given with p<0.001


Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
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