Hepatitis B Virus infection is not a risk factor in liver fluke-associated cholangiocarcinoma – a comparative study of P53 mutation between groups with Opisthorchis viverrini and HBV infection

Publish : December 15, 2014
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Pairojkul C1,Sithithaworn P2, Yongvanit P3, Waraasawapati S1, Chamagramol Y1

1Department of Pathology

2Department of Parasitology and

3Department of Biochemistry

Faculty of Medicine, Khon Kaen Unisersity, Khon Kaen, Thailand

Objective: To investigation the role of HBV infection as a risk factor in liver fluke-associated cholangiocar-cinoma In Northeast (NE) Thailand, people are exposed to numerous risk factors for cholangiocarcinoma, such as: infestation with the liver fluke, Opisthorchis vivenini, hepatitis B virus (HBV) and hepatitis c virus (HCV) infection, and nitrosamine contamination from traditional fermented dishes. The meta-analysis of Asian cholangiocarcinoma revealed that the relative risks of infection with liver fluke, HBV and HCV were 4.8,2.6, and 1.8, respectively. Among Thai people the prevalence ofHBsAg, and anti- HCV were 8-10% and 0.89-5%, respectively.

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Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com