Comparison of triple-dose single-donor platelet collection by the AmicusTM and the Trima Accel® blood-cell separators

Publish : March 15, 2016
Total Download : 12

Woraprapa Apaikawee1, Viroje Chongkolwatana1,
Sasijit Vejbaeya1, Thanaphak Warindpong1
1Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand,
Corresponding author: Viroje Chongkolwatana
Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital,
Wanglang Road, Bangkoknoi , Bangkok, Thailand 10700
Tel: 662-419-7598 Fax: 662-412-8419
Received : 17th December 2015; Accepted : 2nd February 2016


Objective: The purpose of this study was to compare triple-dose single-donor platelet collection using Amicus™ and Trima Accel® blood-cell separators.
Method: The same 25 donors underwent triple-dose single-donor platelet collection using the Amicus™ and Trima Accel® systems. The target endpoint was > 9.5 × 1011 platelets. Processing time, apheresis characteristics, donor safety, and satisfaction, were evaluated. In all, 18 donors completed the study; all of the resulting 36 donations were evaluated.
Results: The collection effi ciency of both systems were not statistically different (80.25±10.64 vs. 76.63±6.06%, p=0.228), the amount of whole blood volume processed was high (5274.50±874.86 vs. 4428.28±593.09 ml, p <0.001), and it used more infused ACD-A (593.56 ±92.74 vs. 521.17± 72.02 ml, p=0.010). The Trima Accel® process was faster (101.10±16.58 vs. 88.61±16.71 min, p=0.002). Most donors expressed satisfaction. The Trima Accel® system scored higher because its comparative speed (9.17 vs.9.22, p=0.805). After separation into blood constituents, all products had < 5.0 x106 (1.04±3.3 vs. 0.44 ±1.05 x 106/unit, p=0.372) residual white blood cells. No severe adverse reactions were noted with either of the instruments.
Conclusion: Our experimental data showed that triple-dose platelet collection was safe using either system. The platelet yields satisfi ed American Association of Blood Banks (AABB) guidelines.


Address of editorial Corresponce.
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address:,