Advantage of frozen section in management of thyroid nodule with preoperative fine needle aspiration in Siriraj Hospital, Bangkok, Thailand

Publish : June 15, 2013
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Thiraphon Boonyaarunnate, M.D. and Kanchana Amornpichetkul, M.D
Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Correspondence: Kanchana Amornpichetkul
Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand
Email: Kanchana.amo@mahidol.ac.th

Abstract


Objectives: We aimed to evaluate the role of frozen section (FS) and preoperative fine-needle aspiration cytology (FNA) in thyroid nodular lesions. 

Material and Methods: Sixty patients who underwent thyroidectomy with preoperative FNA and intraoperative FS were reviewed. The results were compared with the final histologic diagnosis (FHD) to assess their effectiveness in prediction of malignancy. 

Results: The sensitivity and specificity of FNA were 56% and 100%, respectively and of FS were 88% and 100%, respectively. FNA revealed 34 benign, 16 indeterminate and 10 malignant lesions. All of malignant nodules in FNA were proved to be malignant in both FS and FHD: thirty-two lesions of benign FNA category were agreed with the result in FHD whereas two lesions were diagnosed as malignant and one of them was also diagnosed as malignancy by FS. Six out of 16 lesions of indeterminate FNA category were proved to be malignant in FHD and four of them were also diagnosed as malignancy by FS. 

Conclusions: FS appears to give benefit when the results of FNA are indeterminate or benign. FS may not be necessary in the cases of malignant FNA results.

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Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com