Increased eosinophil levels in HIV-infected patients with high CD4/CD8 ratio Study from 564 patients in Ramathibodi Hospital.

Keywords : cd4 , cd4/cd8 ratio , cd8 , eosinophil , eosinophilia , hiv ,
Publish : June 15, 2013
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Preyarat kaewketthong*, Jaruwan Doydee*, Supachewin Thawenuch*, Thanakorn Thuayset*,
Kalayanee Khupulsup** and Punnee Butthep*
*Hematology Division, **Immunology Division, Department of Pathology, Faculty of Medicine Ramathibodi
Hospital, Mahidol University, Bangkok 10400, Thailand

Correspondence address: Punnee Butthep, PhD.
Department of Pathology, Faculty of Medicine Ramathibodi Hospital
Rama 6 Road, Bangkok, 10400 Thailand
Tel./Fax. 662- 2011378
Short running title: Eosinophilia in HIV-infected patients


Blood from 564 patients infected with human immunodeficiency virus (HIV) were studied for laboratory analysis. The hematological changes including white blood cell count (WBC), percentage and absolute number of lymphocyte and eosinophil were determined by using the Technicon H*3 RTX hematological analyzer. Analysis of blood cell parameters were done within 4 hours after venous blood collection. It was noted that 201(35.6%) out of 564 patients had eosinophilia and 148 (73.6%) out of those 201 patients with
eosinophilia showed increased CD4/CD8 ratio as compared with those in patients with normal eosinophil. Furthermore, we found that the patients with extremely high eosinophilia (greater than 60% eosinophil) had the greatest degree of increased CD4/CD8 ratio. Significant correlation between % eosinophil and absolute CD4 (r = 0.552, p-value = < 0.0001) and between % eosinophil and CD4/CD8 ratio (r = 0.716, p-value = <
0.0001) were also observed. It may be suggested that eosinophil estimation might be used as a simple marker from blood smear observation for an assessment of patient status which could be related to the CD values and possibly prognosis of the HIV-infected patients.


Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address:,