Angioimmunoblastic T-Cell Lymphoma: an Epstein-Barr Virus-Associated, Bilineage Lymphoid Neoplasm

Publish : March 15, 2014
Total Download : 4

Surapong Sorcharoen, MD, Supaporn Suwiwat, PhD.* Winyou Mitarnun, MD.

Department of Pathology, Faculty of Medicine Prince of Songkla University, Hat-Yai, THAILAND 90110
Correspondence : Winyou Mitarnun, MD
E-mail: miwinyou@medicine.psu.ac.th
Tel: +66 074 45 1551 Fax: +66 074 212908
Received : 13 Nevember 2013; Accepted : 2 February 2014

ABSTRACT

In this study, 50 cases of angioimmunoblastic T-cell lymphoma (AITL) were investigated for histological patterns, their association with Epstein-Barr virus (EBV) infection, B cell and T cell clonalities, and the clini- cal outcomes. Three histological patterns were identified: the classical pattern (34 cases), large-cell rich pat- tern (14 cases), and interfollicular pattern (2 cases). The median survival time of patients from this group was 36 months. There was no significant difference in survival between patients from the classical pattern and the large-cell rich pattern. EBV-encoded early RNAs (EBERs) in tumor cells were identified in 46% of the cases. The expression of EBERs had no correlation with the histological patterns. We detected T-cell receptor- gamma chain (TCR-g) T-cell clones in 70% of the cases, and immunoglobulin heavy chain (IgH) B-cell clones in 32% of the cases. Bilineage monoclonal proliferation of both T and B cells were detected in 28% of the cases. Clonal B cell expansion had no correlation with number of B cells in the lymph node and the status of EBERs in the tumor cells. Based on the findings from molecular study, we believe that AITL is a bilineage lymphoid neoplasm and may contribute to the pathogenesis of composite lymphomas.

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Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com