Frontoethmoidal encephalomeningocele histopathology and proposed mechanism of developing lesion

Publish : December 15, 2012
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Chariyabhorn Khamjai, M.D.
Department of Anatomical Pathology, Maharat Nakhonratchasima Hospital, Nakhornratchasima 30000, Thailand
Tumtip Sangruchi, M.D.
Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University 2 Prannok Rd. Bangkok 10700,Thailand
Tel. + 66 -02- 4196504 FAX + 66 -02- 4114260


The purpose of this study is to describe histopathological fi ndings of frontoethmoidal meningoencephalocele (FEEM), and to correlate with the embryogenesis.  The study materials were gathered from 86 cases of FEEM, during 1995-2005. The histopathology was observed in terms of the pattern of the lesion, the relation to the skin and surrounding soft tissue, and the differentiation of cell components. The histopathology was described as solid, disperse and reticular patterns of mature neuroepithelium and meningothelial tissue with varying amount of fi brosis. The lesions occupied the dermis, subcutaneous fat and facial muscle. The dermal-epidermal junction was not involved. Regarding histopathology and embryogenesis, misplaced primitive neuroepithelium in the early embryonic stage before development of the epidermis, muscle and bone are the proposed pathogenesis from this study mechanism for developing such lesion.


Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
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