Contribution of MYC FISH in Pathological Diagnosis of Burkitt Lymphoma

Publish : September 15, 2015
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Ubon Poumsuk1, Thiamjit Chaichana1, Preecha Ruangvejvorachai1, Thamathorn Assanasen1 and Shanop Shuangshoti1,2
1Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, THAILAND
2Chulalongkorn GenePRO Center, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, THAILAND

Correspondence : Shanop Shuangshoti, MD
E-mail : Shanop@gmail.com
Tel : +662 256 4235
Fax : +662 652 4208
Received : 10 April 15; Accepted : 5 June 15

ABSTRACT

Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma typically with MYC rearrangement. Distinction between BL and diffuse large B cell lymphoma (DLBCL) is not infrequently encountered in routine practice. In this communication, we report our experience with the MYC break-apart probe FISH in the diagnosis of BL in 19 cases of aggressive B-cell lymphoma. BL was the final diagnosis in 10/19 cases (52.63%),
and 9 of them were shown to carry MYC gene rearrangement. DLBCL was the final diagnosis in 7 cases and all had negative FISH test. B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL were diagnosed in the remaining 2 cases, and one of them showed MYC rearrangement. To summarize, identification of MYC gene rearrangement by FISH assay helps supporting the diagnosis of BL in most of the cases.

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Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com