P-cadherin and CD10 expression to distinguish between ductal carcinoma in situ and invasive ductal carcinoma of the breast

Publish : June 15, 2016
Total Download : 5

Sittipong Wangsawibul M.D.
Faculty of medicine, Prince of Songkla University
 
ABSTRACT
 
Objective: To utilize immunohistochemistry techniques using P-cadherin and CD10 antibodies for evaluating the expression in DCIS and IDC for distinguishing between these entities
Methods: Forty-eight cases of DCIS group, eighteen cases of equivocal group and seventeen cases of IDC grade I group were evaluated. The results were recorded as intensity of staining from 0 to 3+ (≥1+ were considered positive). The positive cases were recorded as percentage of staining (<10%, 10-90% and >90%).
Results: For myoepithelial cells expression, P-cadherin was positive in most cases of DCIS and equivocal groups (79% and 61%, respectively). CD10 was positive in most cases of DCIS and equivocal groups (98% and 72%, respectively). For luminal cells expression, P-cadherin was positive in most cases of DCIS group, all cases of equivocal groups and most cases of IDC grade I group (83%, 100% and 88%, respectively). CD10 was negative in most cases of DCIS and equivocal groups (87% and 94%, respectively) and was negative in all cases of IDC grade I group. For myofi broblasts expression, CD10 was positive in 30% of cases while P-cadherin expression was negative.
Conclusion: P-cadherin had high sensitivity for breast myoepithelial cells but showed low sensitivity due to marked luminal cells expresion. P-cadherin had less benefi t for distinguishing between DCIS and IDC comparing with CD10 but it may aid diagnosis in cases that showed myofi broblastic expression of CD10.
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Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com