Kanapon Pradniwat, MD, Jitsupa Treetipsatit, MD
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University
Corresponding author: Jitsupa Treetipsatit, MD
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University,
2 Prannok Road, Bangkok Noi, Bangkok 10700, Thailand Phone: 662-419-6520
E-mail address: firstname.lastname@example.org Received: 12 August 2013; Accepted : 28 September 2013
The term “undifferentiated” tumor is commonly used by pathologists when a tumor lacking evidence of lineage differentiation on the basis of routine light microscopic morphology is encountered. Immunohisto- chemistry plays an important role in elucidating the true nature of the undifferentiated tumor that is crucial for clinical management. Since undifferentiated round cell tumors can be mimicked by different types of tumors and often cause diagnostic problems especially in small biopsy specimen, the aim of this review is to provide a practical approach to select helpful immunohistochemical markers, a proposed algorithmic approach and pitfalls that may encountered.