A practical approach to undifferentiated tumors: A review on helpful markers and common pitfalls

Publish : September 15, 2013
Total Download : 14

Kanapon Pradniwat, MD, Jitsupa Treetipsatit, MD
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University

Corresponding author:
Jitsupa TreetipsatitMD

Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University,
2 Prannok Road, Bangkok Noi, Bangkok 10700, Thailand Phone: 662-419-6520
Fax: 662-411-4260

E-mail address: jtreetipsatit@gmail.com Received: 12 August 2013; Accepted : 28 September 2013


The term “undifferentiated” tumor is commonly used by pathologists when a tumor lacking evidence of lineage differentiation on the basis of routine light microscopic morphology is encountered. Immunohisto- chemistry plays an important role in elucidating the true nature of the undifferentiated tumor that is crucial for clinical management. Since undifferentiated round cell tumors can be mimicked by different types of tumors and often cause diagnostic problems especially in small biopsy specimen, the aim of this review is to provide a practical approach to select helpful immunohistochemical markers, a proposed algorithmic approach and pitfalls that may encountered.


Address of editorial Corresponce.
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com