Auther : M.D

The effect of calcitonin upon the proliferation of giant cell tumor ; Preliminary of 9 cases

Giant cell tumor is one of the most common primary bone tumors in adult. Current therapy is still curettage and bone graft packing with adjuvant chemical and thermal cautery. However, the rate of recurrence is rather high ranging from 20 to 85 % and many attempts have been made to decrease this rate. Some inves- tigators showed that the cells of...Continue reading →

Frontoethmoidal encephalomeningocele histopathology and proposed mechanism of developing lesion

The purpose of this study is to describe histopathological fi ndings of frontoethmoidal meningoencephalocele (FEEM), and to correlate with the embryogenesis. The study materials were gathered from 86 cases of FEEM, during 1995-2005. The histopathology was observed in terms of the pattern of the lesion, the relation to the skin and surrounding soft tissue,...Continue reading →

Loop-mediated isothermal amplification for detection of Mycobacterium tuberculosis and evaluation in paraffin-embedded lymph nodes

Tuberculosis is a treatable disease, but remains a major cause of mortality. Culture for Mycobacterium is needed to make a definitive diagnosis; thus, loop-mediated isothermal amplification (LAMP) was attempted for its detection in formalin-fixed, paraffin-embedded (FFPE) samples. Materials and method: Archival FFPE blocks were used from 64 patients...Continue reading →

Rate of Dyserythropoiesis-like Nuclear Changes in Erythroid Precursors in Bone Marrow

Dyserythropoiesis-like post-mortem changes in erythroid precursors at autopsy can look similar to certain kinds of primary marrow diseases. This study is designed to evaluate nuclear changes in erythroid precursors in marrow aspirate smears and histologic sections at different intervals after taken out from the body (delayed fi xation) simulating post-mortem changes....Continue reading →

Is immunohistochemistry mandatory in staging bone marrow trephine biopsy of patients with diffuse large B-cell lymphoma (DLBCL)

...Continue reading →

Molecular diagnosis of synovial sarcoma: A comparative study with histologic correlation in Ramathibodi Hospital

Synovial sarcoma (SS) is a relatively common sarcoma of soft tissue arising on extremities of young adult, which is often diagnosed by histology and immunohistochemistry. Synovial sarcoma can have various locations and may cause diagnostic dilemma in tumors arising on unusual locations. In this study, we evaluate the application of molecular test...Continue reading →

Disseminated Tuberculosis in a Mother with Diffuse Large B-cell Lymphoma resulting in Placental and Inferred Congenital Tuberculosis: An Autopsy Case Report

Tuberculosis of the placenta is a rare condition which mainly occurs in the immunosuppressed individuals especially in acquired immune deficiency syndrome (AIDS) and hematologic malignancy9. Tuberculosis can spread to the fetus via hematogenous or cervicovaginal route and result in congenital tuberculosis....Continue reading →

Incomplete pentalogy of Cantrell: a case report

Pentalogy of Cantrell is a rare congenital syndrome characterized by defects involving the supra-umbilical abdominal wall, lower sternum, anterior diaphragm, pericardium, and the intra-cardiac anomalies. The ensuing congenital heart disease is a source of major morbidity. The full spectrum of the syndrome is rare while incomplete expression of the...Continue reading →

Mantle cell lymphoma presenting as multiple lymphomatous polyposis of colon: A case report.

Mantle cell lymphoma is a clinically aggressive lymphoma with a poor prognosis. Secondary involvement of gastrointestinal tract by this neoplasm is not uncommon but the primary involvement with distinguished multiple lymphomatous polyposis is unusual. We report a case of mantle cell lymphoma presenting as multiple lymphomatous...Continue reading →

Advantage of frozen section in management of thyroid nodule with preoperative fine needle aspiration in Siriraj Hospital, Bangkok, Thailand

We aimed to evaluate the role of frozen section (FS) and preoperative fine-needle aspiration cytology (FNA) in thyroid nodular lesions. ...Continue reading →

Non-functioning adrenal cortical adenoma arising in adrenohepatic fusion, mimicking hepatocellular carcinoma – a case report

Adrenal cortical adenoma arising in adrenohepatic fusion is an exceedingly rare occurrence. It can potentially be misinterpreted as hepatocellular carcinoma as they share radiologic and histologic similarities. We report an incidental subcapsular adrenal cortical adenoma arising in adrenohepatic fusion tissue in segment 7 of the liver...Continue reading →

Soft tissue vascular malformations differentiating flow types by MR imaging and comparison with histopathology

To evaluate the MR imaging features of pathologically diagnosed high and low flow vascular malformations....Continue reading →

Molecular diagnosis of synovial sarcoma: A comparative study with histologic correlation in Ramathibodi Hospital

Synovial sarcoma (SS) is a relatively common sarcoma of soft tissue arising in extremities of young adult, which is often diagnosed by histology and immunohistochemistry (IHC). Synovial sarcoma can be found in various locations and may cause diagnostic dilemma in tumors arising in unusual locations. In this study, we evaluated the application of...Continue reading →

Sperm Extraction from Absorbed Filter Paper by Shaking Method

This study would like to to show an easy and effective way (method) for sperm extraction. The method could be used as basic extraction of sperm from absorbed material; such as swab, cotton or fi lter paper. Materials and...Continue reading →

Diagnostic accuracy of fine needle aspiration cytology of salivary glands

Fine needle aspiration (FNA) cytology of suspected salivary gland lesions has an established role in preoperative diagnosis and management of patients. However diverse morphological patterns and overlapping features make it a challenging job, to give a precise diagnosis, at times. The aim of the present study is to investigate the accuracy...Continue reading →

Sclerosing Polycystic Adenosis of the Parotid Gland: Report of A Case with Multifocality

Sclerosing polycystic adenosis (SPA) is a rare tumor-like lesion of the salivary gland that bears a histomorphological resemblance to fibrocystic disease and sclerosing adenosis of the breast. The lesion is widely considered to be a pseudoneoplastic inflammatory process. However, foci of epithelial dysplasia and carcinoma in situ can occur in the...Continue reading →

Primary sinonasal mucosal melanoma with CD138 expressed plasmacytoid cells: a case report and review of literature

Primary sinonasal mucosal melanoma is a rare neoplasm. Like in other sites of malignant melanoma, the histopathology is variable and when lacking of melanin pigment, particularly in small biopsy specimen mimicks many neoplasms. Immunohistochemical staining plays an important role. Many immunomarkers, including S-100, HMB-45 and Melan-A should be...Continue reading →

Chondrosarcoma of distal phalanx with imaging study; a report of rare case with review of the literature

Chondrosarcoma of distal phalanx is extremely rare and to our best knowledge there was only one case having magnetic resonance ( MR ) imaging study. We report a case of 56-year-old woman developing chondrosarcoma of distal phalanx of the left ring finger. The radiographic and imaging studies highly suggested chondrosarcoma and amputation of distal...Continue reading →

Predictive Relevance of Tumor-infiltrating Lymphocytes in Breast Cancer

To determine the prognostic significance of the immunophenotype, density and distribution of tumor-infiltrating lymphocytes (TILs) in breast cancer samples....Continue reading →

Axillary lymph node ratio is an independent prognostic factor in Thai breast cancer patients

The number of metastatic lymph nodes to the total number of dissected axillary lymph nodes (lymph node ratio: LNR) is described as an independent prognostic factor in breast cancer patients, beside the traditional account of the number of axillary lymph node metastasis (pN stage). We investigated the correlation between LNR and prognosis among Thai...Continue reading →

Hepatic injury in patients with colorectal liver metastasis in Thailand

The treatment of colorectal liver metastasis is surgical resection. The chemotherapy can convert unresectable lesions to resectable lesions. However chemotherapy also causes liver injuries in remaining liver parenchyma, such as steatosis, steatohepatitis and sinusoidal dilation. These lesions cannot be distinguished from other causes,...Continue reading →

Fine Needle Aspiration and Core Needle Biopsy for Diagnosis of Mediastinal Mass in Thailand

To evaluate diagnostic accuracy of fi ne needle aspiration (FNA) and core needle biopsy (CNB) in mediastinal lesions. Material and Methods: From October 2006 to September 2015, there were 45 cases of FNA and 87 cases of CNB included in this retrospective study. Results of FNA and CNB were compared with subsequent resection specimen...Continue reading →

Clinicopathological Features of Primary Thyroid Lymphomas in Thailand

Primary non-Hodgkin lymphoma (NHL) of the thyroid is a rare tumor. Some studies show association between thyroid lymphomas and concomitant thyroid diseases, mainly lymphocytic thyroiditis. However, this tumor has not been studied in Thailand. .Therefore, herein, we reviewed clinicopathological features of primary thyroid lymphoma including associated thyroid lesions....Continue reading →

Evaluation of thyroid fine needle aspiration cytology by the Bethesda reporting system: a retrospective analysis of rates and outcomes from the King Chulalongkorn Memorial Hospital

Fine-needle aspiration (FNA) cytology is a gold standard for preoperative evaluation of thyroid nodules. Recently introduced, the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has attempted to standardize reporting and cytological criteria in aspiration smears. This reporting format suggested six diagnostic categories, briefl y defi ned as follows...Continue reading →

Clinicopathological Correlation of Glomerular Mesangial C4d Staining and renal outcome in IgA Nephropathy: A retrospective Cohort Study in Ramathibodi Hospital

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, particularly in Asia. Clinical manifestations vary from asymptomatic to end stage renal disease (ESRD). Currently, several studies have introduced new markers to predict prognosis including C4d which is correlated with poor clinical course....Continue reading →

Evaluation of Adequacy and Diagnostic Histopathology Results of Endometrial Specimens Obtained by Endometrial Aspiration Procedure in Srinagarind Hospital, Khon Kaen University.

The purpose of this investigation is to evaluate the adequacy of endometrial specimens obtained by endometrial aspiration procedures using Pipelle® Endometrial Suction Currette, to determine the minimum microscopic area of endometrial fragments adequate for diagnosis, and to make a correlation between the initial diagnoses of the...Continue reading →

P-cadherin and CD10 expression to distinguish between ductal carcinoma in situ and invasive ductal carcinoma of the breast

To utilize immunohistochemistry techniques using P-cadherin and CD10 antibodies for evaluating the expression in DCIS and IDC for distinguishing between these entities...Continue reading →

Discrepancies between clinical and autopsy diagnosis in traumatic death cases in Siriraj Hospital

Hospital autopsy has been questioned regarding its utility, effectiveness, and validity. However, some discrepancies between clinical and autopsy diagnosis has been shown in previous study.While forensic autopsy, which is mostly done in traumatic death, has not been evaluated for its usefulness, the authors would like to determine...Continue reading →

Agreement between Rapid On-site Evaluation and Final Cytologic Diagnosis of Salivary Gland Specimens

To evaluate diagnostic agreement and compare the performance (accuracy) between rapid onsite evaluation (ROSE) and the fi nal cytologic diagnosis of salivary gland specimens....Continue reading →

Comparison of embalming techniques between formaldehyde and salt solution in human liver and brain

Formaldehyde exposure is a risk factor for cancer in humans. Recent studies have revealed that salt solution can preserve human and animal tissues with a quality equal to formaldehyde. This study is the fi rst attempt to compare effectiveness between formaldehyde and salt solution preservation by quantitative measurement of tissue discoloration, ...Continue reading →

Impact of the 2011 IASLC/ATS/ERS International Multidisciplinary Classifi cation on small biopsies of primary lung cancer: experience in King Chulalongkorn Memorial Hospital from 2012-2014

The 2011 international association for the study of lung cancer/ American thoracic society/ European respiratory society (IASLC/ATS/ERS ) classifi cation changed the approach for defi nite histologic diagnosis of lung cancer. The objective of this article is to describe the impact of the 2011 IASLC/ATS/ERS classifi cation on small biopsy...Continue reading →

Inflammatory bowel disease: Review of histologic features

Inflammatory bowel disease (IBD) is a chronic infl ammation of the digestive tract with ulcerative colitis (UC) and Crohn’s disease (CD) being among the two most common IBD conditions. To evaluate the effi cacy of diagnosis by histomorphology, the histologic features of ninety Thai patients with IBD were evaluated...Continue reading →

Prevalence of Microsatellite instability (MSI) determined by immunohistochemical staining of MSH6 and PMS2 in patients with colorectal adenocarcinoma

Microsatellite instability(MSI) is one of the genetic abnormalities that leads to colon cancer. The defect, known as mismatch repair genes(MMR) can be either sporadic or a germ line mutation. A immunohistochemical study is one of the methods to detect MMR defects. Lots of different treatment modalities and prognosis are needed to distinguish cancer...Continue reading →

Accuracy in distinguishing between primary adenocarcinoma of cervix and adenocarcinoma of endometrium from curettage specimen by immunohistochemistry

Endometrial and endocervical adenocarcinomas can seem histologically identical and it can be diffi cult to determine the primary site of origin based on morphology alone. As the distinction is signifi cant and cannot always be made on the basis of clinical fi ndings, various immunohistochemical panels have been proposed to aid in determining...Continue reading →

Specificity of cytologic features of metastatic lung adenocarcinoma in malignant pleural effusion

Metastatic lung adenocarcinoma is commonly presented with effusions. The cytologic examination of the fl uid is one of the fi rst diagnostic techniques attempted in these patients. Identifi cation of the cancer cells in pleural fl uid specimens, using minimal, less invasive and cost effective intervention is crucial especially...Continue reading →

Automated counting of Ki-67 labeling index compares with eyeballing estimation to predict behavior of pituitary adenoma.

Pituitary adenoma has been classified as benign according to slow-growing tumor. However, some atypical pituitary adenoma may have clinical aggressiveness such as parasellar invasion and high recurrence rate.Many studies have failed to demonstrate a correlation between Ki-67 labeling index and behavior of this tumor....Continue reading →

Placental villous hypermaturation in idiopathic spontaneous preterm births in Srinagarind Hospital

To determine the association between preterm births (PTBs) and placental villous hypermaturation (PVH), a pathological fi nding which suggests placental insuffi ciency....Continue reading →

Astudy of prostatic cancer in radical prostatectomyspecimenand acorrelationwithpre-operativeserum PSA levelin Chiang Mai University Hospital

To assess arelationship between serum prostate specifi c antigen (PSA) levels and pathologic parameters in radical prostatectomy (RP) specimens for prostate cancer in Chiang Mai University Hospital, Chiang Mai, Thailand....Continue reading →

Difficult case in the diagnosis of pineal tumor with ectomesenchymal differentiation: teratoma versus pineal anlage tumor.

Pineal region tumors are rare and heterogeneous including germ cell tumors, pineal parenchymal tumors and neuroepithelial tumors. Amongthe pineal region tumors, germ cell tumorssuch as germinoma and teratoma are the most common, followed by pineal parenchymal tumors. We have discusseda case of 20-year-old woman...Continue reading →

Endometriosis with gut obstruction: a case report of 38 years old woman with acute abdominal pain

A woman, age thirty-eight years old, came to the hospital with acute diarrhea and complained of having severe abdominal pain for two days. She had no underling disease and no history of alcohol or tobacco usage. She previously had surgery for a fracture of the right femur....Continue reading →

Author : Garan Phrommee , M.D. ,

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

The Akt/mTOR pathway is activated in many malignancies including oral squamous cell carcinoma (OSCC). Oral verrucous carcinoma (OVC) is a low grade variant of OSCC. However, the role of the Akt/mTOR pathway in OVC remains unknown. ...Continue reading →

Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com