Auther : MD

Relationship between promoter methylation and protein expression of glutathione S-transferase gene class P1 in breast cancer

Glutathione S-transferase gene class P1 (GSTP1) encodes glutathione S-transferase P1 (GSTP1) that catalyses detoxifying metabolism of glutathione. The lack of GSTP1 expression is linked to carcinogen-esis and is related to promoter methylation. The previous studies of GSTP1 hypermethylation in breast cancer reveal diverse results and suspicious...Continue reading →

Diagnostic Pitfalls of Prostatic Adenocarcinoma in Biopsy Specimens

Prostatic adenocarcioma is a very common male cancer worldwide. Biopsy remains the most reliable means in making definite diagnosis. In the prostate-specific antigen (PSA) screening era, the rate of prostate biopsies rapidly increases, resulting in early detection of very small tumors. In the same time, general pathologists are forced to face...Continue reading →

A practical approach to undifferentiated tumors: A review on helpful markers and common pitfalls

The term “undifferentiated” tumor is commonly used by pathologists when a tumor lacking evidence of lineage differentiation on the basis of routine light microscopic morphology is encountered. Immunohisto- chemistry plays an important role in elucidating the true nature of the undifferentiated tumor that is crucial for clinical management....Continue reading →

Update in Thymoma for Surgical Pathologists

Thymoma is the most common mediastinal tumor in adulthood. By defi nition, it is a thymic epithelial neoplasm that displays at least some characteristics of normal thymus. Microscopically it comprises an admixture of thymic epithelial cells and immature T lymphocytes in various proportions and demonstrates marked intratumoral...Continue reading →

Primary central nervous system lymphoma presenting with panhypopituitarism and diabetes insipidus

Lymphoma involving the hypothalamus is very rare. We present a case of a 48-year-old man with primary central nervous system lymphoma (PCNSL) presenting with hypothalamic and pituitary stalk lesions with frontal masses, causing diabetes insipidus and panhypopituitarism. Brain MRI with gadolinium enhancement demonstrated vivid enhancing hypothalamic and...Continue reading →

Bursitis with pseudosarcomatous fibroblastic proliferation; a case report

Pseudosarcomatous fibroblastic proliferation (PSFP) is a quite common lesion found in various locations in- cluding soft tissue, bone and other organs and often raises a difficult differential diagnosis with malignancy. However, PSFP has not been described in tissue related to bursitis. We report a case of 31-year-old male who developed a cystic...Continue reading →

Traumatic asphyxial death from two-wheel ‘walking behind’ tractor

A 41-year-old man was found suspended 15 cm above the floor, hanging from the long handle-bars of a twowheel ‘walking behind’ tractor. The floor was downward sloping and muddy, which caused the tractor to dig into the floor, raising the long handle bars under the arms of the victim, and pushing him against a pillar....Continue reading →

The role of Immunohistochemistry in diagnosis of renal cell carcinoma subtypes.

To determine the validity of immunohistochemistry in classifying Renal cell carcinoma (RCC) subtypes. Methods: Eighty-three cases of RCC were retrieved. Immunohistochemical staining of Vimentin, CD10, CK7, P504s, Parvalbumin, TFE3, and CD117 were done by using tissue microarray blocks. RCC subtypes were placed and compared with the previous diagnosis....Continue reading →

Impact of CpG site specific methylation on silencing protein expression of GSTP1 in breast cancer

From previous study with Methylation specific polymerase chain reaction (MSP), there were cases of DNA methylation showing positive protein expression. Some CpG sites of the primer were speculated to have no effect on protein expression....Continue reading →

Chondrosarcoma of distal phalanx with imaging study; a report of rare case with review of the literature

Chondrosarcoma of distal phalanx is extremely rare and to our best knowledge there was only one case having magnetic resonance ( MR ) imaging study. We report a case of 56-year-old woman developing chondrosarcoma of distal phalanx of the left ring finger. The radiographic and imaging studies highly suggested chondrosarcoma and amputation of distal...Continue reading →

Angioimmunoblastic T-Cell Lymphoma: an Epstein-Barr Virus-Associated, Bilineage Lymphoid Neoplasm

In this study, 50 cases of angioimmunoblastic T-cell lymphoma (AITL) were investigated for histological patterns, their association with Epstein-Barr virus (EBV) infection, B cell and T cell clonalities, and the clini- cal outcomes. Three histological patterns were identified: the classical pattern (34 cases), large-cell rich pat- tern (14 cases)...Continue reading →

Determination of Asbestos Bodies in Autopsy Lung Fluid

The finding of asbestos bodies in lung fluid aspirates represents definite evidence of having prior exposure to asbestos, and having asbestos fibers entering the bronchial tree. After entering the lung, fibers undergo a coating process with ferritin protein to form asbestos bodies. The present study was carried out with the aim of determining...Continue reading →

Standardization of the Colorectal Carcinoma Surgical Pathology Report

In 2010 Department of Pathology Siriraj Hospital had introduced a standardization program for reporting colorectal carcinoma. Then the completeness and accuracy of pathology reports were assessed. Slides were reviewed for accuracy of pT stage and rectal circumferential margin status. After standardization program the percentage of pT4 lesion...Continue reading →

Comparison of α-smooth muscle actin expression between squamous cell carcinoma and pseudoepitheliomatous hyperplasia

To evaluate the usefulness of α-smooth muscle actin (α-SMA) expression of reactive myofibroblastic cells within desmoplastic reaction tissue for distinction between invasive squamous cell carcinoma (SCC) and pseudoepitheliomatous hyperplasia (PEH)....Continue reading →

Myocardial infarction without coronary artery atherosclerosis: pathological aspect

Myocardial infarction (MI) is a clinico-pathological condition resulted from an irreversible ischemic injury to cardiac myocytes. Myocardial infarction with normal coronary artery on angiogram (MINCA) is a widelyaccepted clinical term used to describe a group of patients presenting with the MI symptoms and signs but having a normal angiogram....Continue reading →

Update in Thymoma for Surgical Pathologists

Thymoma is the most common mediastinal tumor in adulthood. By definition, it is a thymic epithelial neoplasm that displays at least some characteristics of normal thymus. Microscopically it comprises an admixture of thymic epithelial cells and immature T lymphocytes in various proportions and demonstrates marked intratumoral heterogeneity...Continue reading →

Gap Analysis Study before Implementation of Thailand’s National Guidelines for Point of Care Testing at Chiang Rai Province

The Bureau of Laboratory Quality Standards has published Thailand’s National Guidelines for Point-of-Care Testing (POCT) since August 2015. Still yet, the implementation of the guidelines is a great challenge....Continue reading →

Thrombotic microangiopathy with Atypical Posterior Reversible Encephalopathy Syndrome (PRES) after kidney transplantation. A case report.

Neurological manifestation of thrombotic microangiopathy (TMA) after renal transplantation is rare and difficult to be distinguished from other conditions. A 51-year-old female with ESRD of unknown etiology received deceased donor kidney transplantation from a 57-year-old donor....Continue reading →

Address of editorial Corresponce
✎  Vorachai Sirikulchayanonta, MD, Editor-in-Chief: Asian Archives of Pathology, Faculty of Science, Rangsit University, Pathumthani 12000, Thailand.
✉  Email address: asianarchpath@gmail.com, vorachai7@gmail.com