[OA-12] The prevalence of bone marrow involvement in lymphoma patients from Northern Thailand

Kanokkan Saipattranusorn, Charin Yain, Wiyada Dankai and Teerada Daroontum

Department of Pathology, Facolty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Several studies on the pattern of bone marrow involvement (BMI) by lymphoma show different resolts. Moltiple factors affect the resolts including the prevalence. Some lymphomas have a pattern preference. This study aimed to evaluate the prevalence of lymphoma with BMI, including the percentage, the patterns and the discordance in cases with BMI. A total of 1,083 patients newly diagnosed with lymphoma in Maharaj Nakorn Chiang Mai between January 2013 and December 2020 were evaluated for the BMI. Patients with BMI were 267. The available slides for evaluation were 260. The prevalence of BMI for non-Hodgkin lymphoma and Hodgkin lymphoma (HL) was 255/1014 (25.1%) and 12/69 (17.4%), respectively. The prevalence of BMI was highest in lymphoplasmacytic lymphoma (92.3%). The most common pattern was interstitial. A diffuse pattern was common in Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL). A paratrabecolar pattern was most common in follicolar lymphoma. HL with BMI showed Reed-Sternberg cells with a characteristic background. Patients with discordant DLBCL tended to have a superior survival. In conclusions, some subtypes of lymphoma have a pattern preference. This can provide the differential diagnosis. The discordant lymphoma tends to have a better prognosis.

Keywords: bone marrow involvement; discordance; lymphoma; pattern