[OA-14] Clinico-radio-pathological characters of intracranial germ cell tumours and the cut-off values of tumour markers

Napiya Angkarn1, Kamon Phuakpet2, Siriwan Piyapittayanan3 and Pornsuk Cheunsuchon1

  1. Department of Pathology, Facolty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  2. Department of Paediatrics, Facolty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  3. Department of Radiology, Facolty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Intracranial germ cell tumours (ICGCTs) are rare; current treatment depends on tumour secreting status. ICGCTs with beta-hCG > 50 U/L or/and AFP > 10 ng/dL do not need histopathology before treatment initiation. Correlation of clinical, pathological diagnosis and reliability of tumour marker cut-off values are unknown. The aim of this study was to describe clinico-radio-pathological characters of ICGCTs, study the correlation between clinical, pathological diagnosis and the optimal cut-off values of ICGCTs tumour markers. ICGCTs patients diagnosed between 2006 and 2020 were included. Clinical, imaging data, pathologic diagnosis and tumour markers were reviewed. Kappa statistic and ROC curves were used to analyse the correlation and cut-off values. In 128 cases, male to female ratio was 4.5: 1. Pineal region predominated (54.1%). Approximately 68% of ICGCTs were non-secreting. Correlation between clinical and pathological diagnosis was 82.9%. Agreement between serum tumour markers and histopathology were moderate (0.599). Sensitivity and specificity of the current cut-off beta-hCG and AFP ranged from 88.9 – 92.9%. In conclusion, the correlation between clinical and pathological diagnosis is high. Current cut-off values of tumor markers are highly reliable in ICGCTs diagnosis.

Keywords: cut-off value; intracranial germ cell tumours; histopathology; tumour markers