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Glutathione S-transferase gene class P1 (GSTP1) encodes glutathione S-transferase P1 (GSTP1) that catalyses detoxifying metabolism of glutathione. The lack of GSTP1 expression is linked to carcinogen-esis and is related to promoter methylation. The previous studies of GSTP1 hypermethylation in breast cancer reveal diverse results and suspicious...

Giant cell tumor is one of the most common primary bone tumors in adult. Current therapy is still curettage and bone graft packing with adjuvant chemical and thermal cautery. However, the rate of recurrence is rather high ranging from 20 to 85 % and many attempts have been made to decrease this rate. Some inves- tigators showed that the cells of...