Impact of CpG site specific methylation on silencing protein expression of GSTP1 in breast cancer

From previous study with Methylation specific polymerase chain reaction (MSP), there were cases of DNA methylation showing positive protein expression. Some CpG sites of the primer were speculated to have no effect on protein expression....

Author : Valla Fongchaiya, BSc *, Pichet Sampatanukul, MD, MSc*, and Kris Chatamra, MD, FRCS **
Keyword : breast cancer, cpg site, dna methylation, gstp1, protein expression
Category : Original Articles

Relationship between promoter methylation and protein expression of glutathione S-transferase gene class P1 in breast cancer

Glutathione S-transferase gene class P1 (GSTP1) encodes glutathione S-transferase P1 (GSTP1) that catalyses detoxifying metabolism of glutathione. The lack of GSTP1 expression is linked to carcinogen-esis and is related to promoter methylation. The previous studies of GSTP1 hypermethylation in breast cancer reveal diverse results and suspicious...

Author : Supparit Pakdeethai BSc, Valla Fongchaiya BSc, Tanett Pongtheerat PhD., Kroon- pong Iampenkhae MD., Pichet Sampatanukul MD. MSc
Keyword : breast cancer, glutathione s-transferase, gstp1, promoter methylation
Category : Original Articles