anaplastic lymphoma kinase

ALK-positive large B-cell lymphoma (ALK-positive LBCL) is a rare type of lymphoma. Because of the overlap of morphological and immunophenotypic features with other haematologic and non-haematologic neoplasms, diagnosing ALK-positive LBCL can be challenging. The lymph nodes showed a marked diffuse infiltrate of monomorphic large immunoblast-like cells with round pale nuclei containing a large central nucleolus and abundant amphophilic cytoplasm. Lymphoma cells were strongly positive for the ALK protein. ...