Comparison of α-smooth muscle actin expression between squamous cell carcinoma and pseudoepitheliomatous hyperplasia
To evaluate the usefulness of α-smooth muscle actin (α-SMA) expression of reactive myofibroblastic cells within desmoplastic reaction tissue for distinction between invasive squamous cell carcinoma (SCC) and pseudoepitheliomatous hyperplasia (PEH)....
Determination of Asbestos Bodies in Autopsy Lung Fluid
The finding of asbestos bodies in lung fluid aspirates represents definite evidence of having prior exposure to asbestos, and having asbestos fibers entering the bronchial tree. After entering the lung, fibers undergo a coating process with ferritin protein to form asbestos bodies. The present study was carried out with the aim of determining...
Impact of CpG site specific methylation on silencing protein expression of GSTP1 in breast cancer
From previous study with Methylation specific polymerase chain reaction (MSP), there were cases of DNA methylation showing positive protein expression. Some CpG sites of the primer were speculated to have no effect on protein expression....
The role of Immunohistochemistry in diagnosis of renal cell carcinoma subtypes.
To determine the validity of immunohistochemistry in classifying Renal cell carcinoma (RCC) subtypes. Methods: Eighty-three cases of RCC were retrieved. Immunohistochemical staining of Vimentin, CD10, CK7, P504s, Parvalbumin, TFE3, and CD117 were done by using tissue microarray blocks. RCC subtypes were placed and compared with the previous diagnosis....
Primary central nervous system lymphoma presenting with panhypopituitarism and diabetes insipidus
Lymphoma involving the hypothalamus is very rare. We present a case of a 48-year-old man with primary central nervous system lymphoma (PCNSL) presenting with hypothalamic and pituitary stalk lesions with frontal masses, causing diabetes insipidus and panhypopituitarism. Brain MRI with gadolinium enhancement demonstrated vivid enhancing hypothalamic and...
The Many Faces (and Origins) of Adenocarcinoma in the Liver: Pattern Approach to Diagnosis on Small Tissue Samples
Focal liver lesions can be solitary or multiple, solid or cystic, congenital or acquired, and range from cysts, hamartomas, hyperplastic nodules and inflammatory entities to tumors and tumor-like lesions. The background liver may be normal or diseased. An algorithmic approach based on pattern recognition and cell profiling is outlined for the ...
Relationship between promoter methylation and protein expression of glutathione S-transferase gene class P1 in breast cancer
Glutathione S-transferase gene class P1 (GSTP1) encodes glutathione S-transferase P1 (GSTP1) that catalyses detoxifying metabolism of glutathione. The lack of GSTP1 expression is linked to carcinogen-esis and is related to promoter methylation. The previous studies of GSTP1 hypermethylation in breast cancer reveal diverse results and suspicious...
