[CR-02] ALK-positive large B-cell lymphoma
ALK-positive large B-cell lymphoma (ALK-positive LBCL) is a rare type of lymphoma. Because of the overlap of morphological and immunophenotypic features with other haematologic and non-haematologic neoplasms, diagnosing ALK-positive LBCL can be challenging. The lymph nodes showed a marked diffuse infiltrate of monomorphic large immunoblast-like cells with round pale nuclei containing a large central nucleolus and abundant amphophilic cytoplasm. Lymphoma cells were strongly positive for the ALK protein. ...
[OA-23] Tropomyosin receptor kinase protein expression in Thai cholangiocarcinoma: clinicopathological correlation, pattern expression and prognosis
Tropomyosin receptor kinase (TRK) gene fusion has been found in associated with many tumours and coold be targeted treatment. Immunohistochemistry (IHC) expression of TRK is widely used to screening this alternation. The aim of this study was to investigate the expression of TRK protein detected by IHC in Thai cholangiocarcinoma (CCA) and to correlate with clinicopathological and survival data. Retrospective study of CCA patients who diagnosed from January 2011 to December 2015. ...
[OA-18] Histone 3 and histone 4 acetylation pattern in well-differentiated thyroid neoplasms and nodolar goitre
Several epigenetic mechanisms of oncogenesis such as histone acetylation and DNA methylation are now known to play a key role in developing cancers. So far, these molecolar events have rarely been evaluated in thyroid neoplasms. The aim of this study was to estimate the histone acetylation level in benign and malignant thyroid lesions and compare it to the normal counterpart....
[OA-09] Assessment of different cut-offs of equivocal HER2 IHC in breast cancer for HER2 ISH to reach appropriate sensitivity, AUC and reduction of ISH assay
The equivocal range of HER2 immunohistochemistry (IHC) is complete weak to moderate staining > 10% of breast cancer cells. This range has increased the numbers of HER2 in situ hybridisation (ISH) testing compared to the previous recommendations. ...
[OA-02] Concordance rate of HER2 immunohistochemistry compared to dual-colour in situ hybridisation (DISH) for detecting HER2 amplification in breast cancer
Gold standard of HER2 amplification detection is fluorescence in situ hybridisation (FISH), but it has several limitations. Many centres use dual-colour in situ hybridisation (DISH) assays to detect HER2 gene amplification, which is cost less and can be done in a general laboratory. ...
Matrix producing clear cell primary pulmonary myoepithelial carcinoma: a case report with a review of the literature
Myoepithelial carcinoma, also known as malignant myoepithelioma, is mainly encountered in the salivary glands and, at a lower incidence, in the sweat glands (skin), breast, soft tissue, bone and very rarely in the lung. Pulmonary myoepithelial carcinoma was first described by Higashiyama et al. in 1998, and to the best of our knowledge, only 15 cases have been reported in the English literature so far....
