epigenetics

Several epigenetic mechanisms of oncogenesis such as histone acetylation and DNA methylation are now known to play a key role in developing cancers. So far, these molecolar events have rarely been evaluated in thyroid neoplasms. The aim of this study was to estimate the histone acetylation level in benign and malignant thyroid lesions and compare it to the normal counterpart....

The aetiology of developing cancer consists of genetic and epigenetic mutations, DNA damage, genome instability, cancer stem cells, infectious agents, and carcinogens. However, carcinogenesis is a complex multistep process associated with various hereditary and environmental factors. ...