[P-01] A study of the MRI and pathologic features of 66 cases of primary central nervous system lymphoma
Truong Phan Xuan Nguyen1 and Thi Ngoc Ha Hua2
- Department of Pathology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
- Department of Pathology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
Background and Objectives: Primary central nervous system lymphoma (PCNSL) was an uncommon variant of extranodal non-Hodgkin lymphoma. Contrast-enhanced MRI imaging was the method of choice for detecting PCNSL. The purpose was to describe the MRI and pathologic features of PCNSL and to determine whether there was a correlation between it.
Materials and Methods: A series of 66 cases of PCNSL were diagnosed at the Department of Pathology, Cho Ray Hospital, from January 2016 to November 2018.
Results: Sixty-six cases were immunocompetent which had mean age 55 ± 12 years old. The monofocal lesion was predominant (77.27%). Basal ganglia and periventricular brain parenchyma were the most common site of involvement (23.86%). The mean size was 3.80 ± 1.78 cm. The lesions were hyperintense on T1-weighted images (66.67%), and 89.39% hypointense on T2-weighted images. These patients had enhancing lesions (98.48%) and perifocal oedema (36.36%). Diffuse large B-cell lymphoma (DLBCL) was predominant in all the cases (72.24%). Vascular destruction pattern was presented in high proportion (χ2, p < 0.05). The correlations between the perivascular infiltrative pattern and the vascular destruction were statistically significant (Fisher, p < 0.05). Corticoid usage before biopsy was related to necrosis (Fisher, p < 0.05). The solid enhancing lesions were correlated with the density of tumour (Fisher, p < 0.05).
Conclusion: PCNSL is a rare tumour in central nervous system. The vast majority of PCNSL have a B-cell origin, particularly DLBCL. In the proper clinical and radiologic setting, suggesting the diagnosis of PCNSL can help institute proper treatment in a timely fashion and avoid unnecessary attempts at surgical resection.
