[P-36] Primary lymphomas of the bone – a case series

Shreya S. and Vidya Monappa

Department of Pathology, Kasturba Medical College, Manipal, India

Background: Primary lymphoma of bone (PLB) is an extranodal lymphoma that arises in osseous sites with no evidence of disease elsewhere for at least 6 months. They account for 3% of malignant bone tumours and 1% of all lymphomas. Secondary involvement of bone by lymphoma. This study analysed the clinicopathological features and outcomes of a series of PLB.

Case Presentation: This was a retrospective study from January 2013 to December 2020. Six cases of PLBs were included. Age ranged from 21 to 62 years old (mean of 45 years old) with no sex predilection. The most common symptom was local bone pain. Sites involved were spine (4 cases) and pelvic bones (2 cases). Histopathology consisted of DLBCL (5 cases), Hodgkin's lymphoma (1 case) and T lymphoblastic lymphoma (1 case). No patients had lymphadenopathy and most patients (4 cases) were stage 4. LDH was elevated in all. Patients underwent local resection (for obstructive symptoms) with adjuvant chemoradiotherapy. Follow-up duration ranged from 1 to 3 year (s) (median of 1 year). One patient succumbed to lung metastasis with respiratory failure.

Discussion and Conclusion: PLBs are very rare tumours. There exists a separate staging system for PLBs. DLBCLs are the commonest type of PBL. On radiology they have no special characteristics. Most cases have a favorable outcome when treated with a combined chemoradiotherapy. It is thus important to differentiate them from other causes of lytic bone lesions including primary and metastatic tumours.