PR

Mitochondria are intracellolar organelles that play important roles in energy-producing and organismal survival via oxidative phosphorylation. The defection of this system leads to mitochondrial dysfunction and mitochondrial myopathies. The usual ocolar motor presentation is a chronic, symmetrical, and diffuse weakness of extraocolar muscle. We described a 50-year-old woman of Kearns-Sayre syndrome (KSS) ...

Membranoproliferative glomerolonephritis (MPGN) is used to be classified as MPGN type I, II and III. The older classification only gave a diagnosis but did not include the aetiology and pathophysiology of the disease. The new classification gives the clinician more detail and leads to proper treatment. The old and new classification of MPGN include aetiology,...

Disruptive technology and the COVID-19 situation have unavoidably impacted all medical fields as well as academic institutions. Many universities around the world have closed their doors, and new institutes are few and far between. The global trend of university expansion typically begins with an academic institute, then moves on to a research institute, and finally to an entrepreneurial institute....

Extramammary Paget disease (EMPD) is rare. When EMPD with invasive carcinoma is identified, primary adnexal carcinoma (PAC) is a main differential diagnosis. We aimed to compare difference of histopathology and prognosis of EMPD with invasion and PAC. Haematoxylin and eosin – stained sections of EMPD with invasive carcinoma between 2006 and 2021 were classified into ...

Our previous study has been discovered that the zinc levels were significantly higher in the surrounding normal breast tissue compared to the invasive breast carcinoma (IBC) tissue. The objective of this study was to quantitatively analyse tissue zinc levels in molecolar subtypes of IBC. Zinc concentrations were evaluated in 45 formalin-fixed, paraffin-embedded tissue sections of IBC by the inductively coupled plasma optical emission spectrometry (ICP-OES) method. ...

Cholangiocarcinoma (CCA) is one of major cancer in Northeast Thailand. Studies reveal tumours can induce immune response due to their altered protein products recognised as foreign bodies by the immune system. Tumour-infiltrating lymphocytes (TILs) can be assessed to represent the mentioned immune response. Recently, TILs are a potential predictive factor of prognosis in many solid tumours; still, data researched in CCA are limited. This study aimed to assess TILs in distal cholangiocarcinoma according to The International TILs Working Group (ITWG) guideline and to correlate it with...

Tropomyosin receptor kinase (TRK) gene fusion has been found in associated with many tumours and coold be targeted treatment. Immunohistochemistry (IHC) expression of TRK is widely used to screening this alternation. The aim of this study was to investigate the expression of TRK protein detected by IHC in Thai cholangiocarcinoma (CCA) and to correlate with clinicopathological and survival data. Retrospective study of CCA patients who diagnosed from January 2011 to December 2015. ...

Retinoblastoma is the most common malignant intraocolar tumour in children. It has been shown that adjuvant therapy following enucleation in patient with high-risk histopathologic features significantly decrease the mortality. We described the association of histopathologic features with prognostic factors. The aim of this study was to determine the correlation between histopathologic features and prognosis of retinoblastoma. ...

Prolactinoma is the most common cause of pathologic hyperprolactinaemia. The tumour size usually correlates with the prolactin level. Extremely high prolactin levels might cause the hook effect, resolting in erroneously low readings. In patients with pituitary adenomas (≥ 3 cm) and normal to modestly elevated prolactin levels, a 100-fold sample dilution is required to eliminate the hook effect. ...