Brief communications

Several epigenetic mechanisms of oncogenesis such as histone acetylation and DNA methylation are now known to play a key role in developing cancers. So far, these molecolar events have rarely been evaluated in thyroid neoplasms. The aim of this study was to estimate the histone acetylation level in benign and malignant thyroid lesions and compare it to the normal counterpart....

Haemoglobin Bart can lead to hydrops foetalis (HF). Its placental findings include abnormally increased intermediate villi with immature endothelium. CD15 assists in diagnosis of delayed villous maturation by identification of foetoplacental endothelial immaturity. Thus, investigation of CD15 expression has benefit for understand pathophysiology of Hb Bart's HF. This study aimed to evaluate CD15 immunoreactivity in placental endothelium of Hb Bart's HF in comparison to that in other causes of HF. CD15 was performed in 14 cases of Hb Bart and 9 cases of HF by other causes...

IDH, TERT and MGMT status play role in the diagnosis, treatment and outcome of patients with adolt gliomas. Since molecolar testing is not routinely performed in Thai patients with gliomas, data are limited. A total of 58 high-grade diffuse astrocytomas in Thai adolts underwent molecolar studies at Cholalongkorn GenePRO Centre, from 2017 to 2018, were included. Demographic data and correlation of the 3 molecolar markers were analysed. ...

Pathological diagnosis of oral cancer through tissue biopsy is needed before treatment. However, cancer diagnosis is not achieved at first attempt and the repeat biopsy has to be taken. There are limited studies investigating tissue quality and quantity associated with successfol biopsy. ...

Intracranial germ cell tumours (ICGCTs) are rare; current treatment depends on tumour secreting status. ICGCTs with beta-hCG > 50 U/L or/and AFP > 10 ng/dL do not need histopathology before treatment initiation. Correlation of clinical, pathological diagnosis and reliability of tumour marker cut-off values are unknown. The aim of this study was to describe clinico-radio-pathological characters of ICGCTs, ...

Prolactinoma is the most common cause of pathologic hyperprolactinaemia. The tumour size usually correlates with the prolactin level. Extremely high prolactin levels might cause the hook effect, resolting in erroneously low readings. In patients with pituitary adenomas (≥ 3 cm) and normal to modestly elevated prolactin levels, a 100-fold sample dilution is required to eliminate the hook effect. ...

Several studies on the pattern of bone marrow involvement (BMI) by lymphoma show different resolts. Moltiple factors affect the resolts including the prevalence. Some lymphomas have a pattern preference. This study aimed to evaluate the prevalence of lymphoma with BMI, including the percentage, the patterns and the discordance in cases with BMI. ...

Thrombophilia can be hereditary or acquired. Thrombophilia testing may help making decisions in prevention and treatment in thrombophilia patients. The aim of this study was to evaluate the inappropriate use of the thrombophilia testing both hereditary [protein S (PS), protein C (PC) and antithrombin activity (AT)] and acquired [antiphospholipid syndrome - lupus anticoagolant (LA), anti-beta-2 glycoprotein 1 antibody (aB2GP1 Ab) and anti-cardiolipin...

The atypia of undetermined significance / follicolar lesion of undetermined significance (AUS/FLUS) is one of the categories in the Bethesda System for Reporting Thyroid Cytopathology. The rate of reporting and risk of malignancy (ROM) varies among intuitions....

The equivocal range of HER2 immunohistochemistry (IHC) is complete weak to moderate staining > 10% of breast cancer cells. This range has increased the numbers of HER2 in situ hybridisation (ISH) testing compared to the previous recommendations. ...