The detection of HLA-B27 allele types by quantitative real-time polymerase chain reaction with melting curve analysis
Human leucocyte antigen B27 (HLA-B27) is a major histocompatibility complex class 1 molecule that is strongly associated with ankylosing spondylitis. The polymerase chain reaction with sequence specific primers (PCR-SSP) is currently used for the discrimination of HLA-B27 allele types resulting from single base substitutions....
Assessment of the usefulness of the knowledge of Pathology for clinical medical students - A multi-center study
Pathology courses are taught to undergraduate medical students to provide them with basic foundation for clinical sciences. However, there is hardly any form of assessment of how relevant and helpful these pathology courses are to the students in the clinical years and even beyond. ...
Predictive Biomarker Testing in Colorectal Cancer: KRAS and BRAF Mutation Frequency and Testing Algorithm in Developing Countries
Predictive biomarker testing is mandatory before initiating targeted therapy in metastatic colorectal cancer (mCRC). Mutation frequencies and their association with clinicopathological features vary widely across populations. In low socio-economic countries, appropriate selection of cases is important for biomarker testing....
Acute and subchronic oral toxicity of xanthones extracted from the pericarp of Garcinia mangostana Linn.in rat
The purpose of this research was to study the acute and subchronic toxicity of crude mangosteen pericarp hydro extract, and determine the appropriate and safe amount of extract that may be consumed, through testing with Sprague Dawley rats of both sexes. The soft layer of the inner pericarp mangosteen fruits was immersed in water and boiled at 70 OC, and...
Contribution of MYC FISH in Pathological Diagnosis of Burkitt Lymphoma
Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma typically with MYC rearrangement. Distinction between BL and diffuse large B cell lymphoma (DLBCL) is not infrequently encountered in routine practice. In this communication, we report our experience with the MYC break-apart probe FISH in the diagnosis of BL in 19 cases of...
Myocardial infarction without coronary artery atherosclerosis: pathological aspect
Myocardial infarction (MI) is a clinico-pathological condition resulted from an irreversible ischemic injury to cardiac myocytes. Myocardial infarction with normal coronary artery on angiogram (MINCA) is a widelyaccepted clinical term used to describe a group of patients presenting with the MI symptoms and signs but having a normal angiogram....
Comparison of α-smooth muscle actin expression between squamous cell carcinoma and pseudoepitheliomatous hyperplasia
To evaluate the usefulness of α-smooth muscle actin (α-SMA) expression of reactive myofibroblastic cells within desmoplastic reaction tissue for distinction between invasive squamous cell carcinoma (SCC) and pseudoepitheliomatous hyperplasia (PEH)....
Standardization of the Colorectal Carcinoma Surgical Pathology Report
In 2010 Department of Pathology Siriraj Hospital had introduced a standardization program for reporting colorectal carcinoma. Then the completeness and accuracy of pathology reports were assessed. Slides were reviewed for accuracy of pT stage and rectal circumferential margin status. After standardization program the percentage of pT4 lesion...
Axillary lymph node ratio is an independent prognostic factor in Thai breast cancer patients
The number of metastatic lymph nodes to the total number of dissected axillary lymph nodes (lymph node ratio: LNR) is described as an independent prognostic factor in breast cancer patients, beside the traditional account of the number of axillary lymph node metastasis (pN stage). We investigated the correlation between LNR and prognosis among Thai...
Predictive Relevance of Tumor-infiltrating Lymphocytes in Breast Cancer
To determine the prognostic significance of the immunophenotype, density and distribution of tumor-infiltrating lymphocytes (TILs) in breast cancer samples....
